中国免疫学杂志2016，Vol.32Issue(3)：410-413,416,5.DOI:10.3969/j.issn.1000-484X.2016.03.025
CD163分子在非小细胞肺癌患者组织中表达及其对肺癌细胞侵袭和增殖的影响
Expression of CD163 in patients of non-small cell lung and effects of cancer cell migration and proliferation
黄冬云 1许文景 1周锐 1徐兴祥 1张旭东1
作者信息
摘要
Abstract
Objective:To investigate the expression of CD 163 in the plasma and tumor tissue of non-small cell lung cancer (NSCLC)patients,and the effects of cancer cell migration and proliferation .Methods:35 cases of NSCLC patients in our hospital as the study group,and 35 healthy volunteers as control group ,we used Real-time RCR to detect the expression of CD163 in the plasma and tumor tissue of NSCLC patients.Using small interfering RNA (siRNA) to inhibit the expression of CD163 in MH-2,and co-culture with A549.The level of cancer cell migration was observed by transwell and the level of cell proliferation was observed by CCK -8.Results:The expression of CD163 in the plasma and tumor tissue of NSCLC patients was significantly higher than the control group , the difference was statistically significant (P<0.05);after the expression of CD163 was suppressed in MH-2,the levels of cancer cell migration and proliferation were significantly decreased , the difference was statistically significant ( P<0.05 ) .Conclusion: The expression of CD163 in the plasma and tumor tissue of NSCLC patients is increased ,and may elevate the levels of cancer cell migration and proliferation.关键词
CD163/NSCLC/侵袭/增殖Key words
CD163/NSCLC/Migration/Proliferation分类
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黄冬云,许文景,周锐,徐兴祥,张旭东..CD163分子在非小细胞肺癌患者组织中表达及其对肺癌细胞侵袭和增殖的影响[J].中国免疫学杂志,2016,32(3):410-413,416,5.
