中国全科医学2016，Vol.19Issue(10)：1151-1155,5.DOI:10.3969/j.issn.1007-9572.2016.10.010
血清性激素结合球蛋白水平对2型糖尿病患者合并代谢综合征的影响研究
Influence of Serum Sex Hormone - binding Globulin Level on Type 2 Diabetes Complicated With Metabolic Syndrome
摘要
Abstract
Objective To investigate the influence of sex hormone - binding globulin( SHBG) on type 2 diabetes mellitus(T2DM)combined with metabolic syndrome(MS). Methods From June 2012 to November 2014,we enrolled 307 T2DM patients who received treatment in the First Hospital Affiliated to China Medical University. Based on the diagnostic criteria of MS,the patients were divided into pure T2DM group( G0 group,n = 82)and group of T2DM plus one item of MS( G1 group,n = 46),group of T2DM plus 2 items of MS(G2 group,n = 61),group of T2DM plus three items of MS(G3 group,n= 71)and group of T2DM plus 4 items of MS( G4 group,n = 47). Clinical data of the five groups were collected,and the influence of SHBG level on T2DM combined with MS was investigated. Results The five groups were not significantly different in gender,age,length of disease,FPG and HbA1c ( P > 0. 05),but were significantly different in BMI,waistline,systolic pressure,diastolic pressure,TG,HDL-C,UA,fasting insulin and HOMA-IR(P < 0. 05). The five groups were significantly different in the SHBG level of males(P < 0. 05),and were also significantly different in that of females(P < 0. 05). There was no significant differences in SHBG level between male and female patients in each group( P > 0. 05). Pearson correlation analysis showed that SHBG level had negative correlation with BMI,waistline,FPG,TG,UA,fasting insulin,and HOMA-IR (P < 0. 05)and had positive correlation with HDL-C( P < 0. 05). Ordinal multi - classification Logistic regression analysis showed that SHBG level had significant influence on T2DM combined with MS( P < 0. 05). Conclusion SHBG level is an influencing factor for T2DM combined with MS,and lower SHBG level is associated with the higher risk.关键词
性激素结合球蛋白/糖尿病,2 型/代谢综合征/胰岛素抵抗Key words
Sex hormone - binding globulin/Diabetes mellitus,type 2/Metabolic syndrome/Insulin resistance分类
医药卫生引用本文复制引用
邱晴,都健,杨晶,敖娜..血清性激素结合球蛋白水平对2型糖尿病患者合并代谢综合征的影响研究[J].中国全科医学,2016,19(10):1151-1155,5.基金项目
辽宁省科学技术厅项目（L2011225020）；沈阳市科学技术项目 （）
