中国全科医学2016，Vol.19Issue(10)：1156-1160,5.DOI:10.3969/j.issn.1007-9572.2016.10.011
经桡动脉入径直接经皮冠状动脉介入治疗术联合替罗非班治疗急性ST段抬高型心肌梗死的临床疗效研究
Clinical Effect of Trans - radial Primary Percutaneous Coronary Intervention Combined With Tirofiban in Patients With Acute ST - elevation Myocardial Infarction
张丽 1丁世芳 1蒋桔泉 2陈志楠 2卢青 2付文波 2彭毅2
作者信息
- 1. 510515 广东省广州市，南方医科大学研究生学院
- 2. 广州军区武汉总医院心血管内科
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of trans - radial primary percutaneous coronary intervention (PCI)combined with tirofiban in patients with acute ST - elevation myocardial infarction(STEMI). Methods From February 2014 to February 2015,we enrolled 95 STEMI patients who underwent successful emergency PCI in Wuhan General Hospital of Guangzhou Military Area Command. According to entry method,the patients were divided into femoral artery entry group( n= 45)and radial artery entry group(n = 50). Comparison was made between the two groups in the success rate of puncture,the success rate of PCI,thrombolysis in myocardial infarction trial of distal blood flow(TIMI)grade of blood flow after surgery,the decrease degree of hemoglobin,the proportion of patients with≥50% resolution of ST - segment involved in infarction one hour after surgery,LVEF one week after surgery,postoperative bleeding status,postoperative coronary intensive care unit( CCU) time,total hospitalization time,major adverse cardiac event( MACE)during hospitalization and 6 - month follow - up and EQ-5D results. Results The two groups were not significantly different in the success rate of puncture and the success rate of PCI (P > 0. 05). The two groups were not significantly different in TIMI grade of blood flow,the decrease degree of hemoglobin after surgery,the proportion of patients with ≥50% ST - segment resolution one hour after surgery and LVEF one week after surgery ( P > 0. 05). The two groups were not significantly different in the proportion of patients with mild TIMI bleeding(P > 0. 05)but were significantly different in the proportion of severe TIMI bleeding(P < 0. 05). The two groups were significantly different in CCU time and total hospitalization time(P < 0. 05). The two groups were significantly different in the incidence of MACE during hospitalization and 6 - month follow up(P < 0. 05). In the evaluation of EQ-5D,the two groups were not significantly different in the three dimensions of movement ability,ability of daily activity and anxiety/ depression(P > 0. 05),while the two groups were significantly different in self - care ability and pain/ discomfort( P < 0. 05). Conclusion Trans - radial primary PCI combined with tirofiban has good clinical efficacy,reduces CCU time and total hospitalization time,reduces the proportion of patients with severe TIMI bleeding after surgery and improves prognosis and quality of life of patients. Therefore,the therapy is worth clinical promotion and application.关键词
心肌梗死/血管成形术,气囊,冠状动脉/替罗非班/治疗结果Key words
Myocardial infarction/Angioplasty,balloon,coronary/Tirofiban/Treatment outcome分类
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张丽,丁世芳,蒋桔泉,陈志楠,卢青,付文波,彭毅..经桡动脉入径直接经皮冠状动脉介入治疗术联合替罗非班治疗急性ST段抬高型心肌梗死的临床疗效研究[J].中国全科医学,2016,19(10):1156-1160,5.
