摘要
Abstract
Objective To investigate the relation between myocardial microcirculation and microalbuminuria in patients with hypertension and chest pain. Methods We enrolled 37 patients with hypertension and chest pain who were admitted into the Department of Cardiology of Huai′an First Hospital Affiliated to Nanjing Medical University from July 2014 to July 2015. Urinary albumin level was measured using immunoturbidimetry,and the ratio of urinary albumin to creatinine(ACR)was calculated;myocardial flow reserve(CFR)was measured by intracoronary pressure wire,and the patients with CFR≥2. 5 were assigned into normal group( n = 15)and patients with < 2. 5 were assigned into low blood flow reserve group( n = 22). Comparison was made between the two groups in general data,biochemical criterion,the indexes of cardiac ultrasound examination,and the indexes of intracoronary pressure wire examination, and the influencing factors for CFR were analyzed. Results The two groups were not significantly different in gender,age,waistline,BMI,24 h average systolic pressure,24 h average diastolic blood pressure,24 h average heart rate,blood glucose,TC,HDL,LDL,TG,SCr and GFR (P > 0. 05);low blood flow reserve group was higher than normal group in ACR( P < 0. 05) . The two groups were not significantly different in LAD,E and A(P > 0. 05);low blood flow reserve group was higher in LVMI and lower in E/ A than normal group(P≤0. 05). The two groups were not significantly different in diastolic blood pressure at baseline and blood flow velocity at congestion stage(P > 0. 05);low blood flow reserve group was higher in blood flow velocity,systolic pressure,pulse pressure and heart rate at baseline and lower in CFR than normal group(P < 0. 05). Negative linear correlation existed between CFR and logACR(r = - 0. 511,P < 0. 01). Multiple linear regression analysis showed that gender,ACR,LVMI and E/ A had significant influence on CFR( P < 0. 05 ) . Conclusion Microalbuminuria is an independent risk factor for myocardial microcirculation damage in patients at early stage of hypertension.关键词
高血压/血流储备分数,心肌/尿清蛋白和肌酐比值/危险因素Key words
Hypertension/Fractional flow reserve,myocardial/Albumin to creatinine ratio/Risk factors分类
医药卫生
