中国全科医学2016，Vol.19Issue(11)：1272-1275,4.DOI:10.3969/j.issn.1007-9572.2016.11.009
不同组织学分型肺腺癌患者的临床特征及预后影响因素研究
Clinical Features of Lung Adenocarcinoma Patients of Different Histological Types and Influencing Factors for Prognosis
刘月平 1刘俊英 1陈砚凝 1丁妍 1贺宇彤 2单保恩2
作者信息
- 1. 050011 河北省石家庄市，河北医科大学第四医院病理科
- 2. 050011 河北省石家庄市，河北医科大学第四医院肿瘤研究所
- 折叠
摘要
Abstract
Objective Retrospective analysis of clinical features of lung adenocarcinoma patients of different histological types and influencing factors,in order to provide references for the definite diagnosis and clinical treatment of early lung adenocarcinoma. Methods A total of 190 patients with stage Ⅰ lung adenocarcinoma who received operative treatment in the Fourth Hospital of Hebei Medical University from November 2008 to November 2012 were enrolled as subjects. Among them, 7 patients had AIS,71 patients had MIA and 112 patients had infiltrating adenocarcinoma. The clinical data of the subjects were collected;pathological diagnosis was taken as the starting point and April 2015 was taken as the end point;death was taken as the outcome event. xTAG liquidchip technology was used to detect the gene mutation of exon 18 - 21 of EGFR gene. Results The three types of patients were significantly different in gender,TNM staging,diameter of tumor and pathogenic site( P <0. 05). The 5 - year survival rate of AIS/ MIA patients was 100. 0% ,and that of infiltrating adenocarcinoma patients was 82. 7% ;significant difference existed among them( χ2 = 13. 591,P < 0. 001). Cox proportional hazards regression model analysis showed that,smoking〔 HR = 0. 084,95% CI(0. 018,0. 391)〕,TNM staging〔 HR = 2. 528,95% CI(1. 081, 5. 911)〕and EGFR gene mutation〔HR = 3. 025,95% CI(1. 279,7. 157)〕were influencing factors for the prognosis of lung adenocarcinoma patients(P < 0. 05). Conclusion Patients with AIS,MIA have good prognosis. Smoking,TNM staging and EGFR gene mutation are influencing factors for the prognosis of lung adenocarcinoma patients. New international classification system is helpful for the prognosis evaluation of lung adenocarcinoma patients.关键词
肺肿瘤/微浸润性腺癌/原位腺癌/病理学/预后Key words
Lung neoplasm/Minimally invasive adenocarcinoma/Adenocarcinoma in situ/Pathology/Prognosis分类
医药卫生引用本文复制引用
刘月平,刘俊英,陈砚凝,丁妍,贺宇彤,单保恩..不同组织学分型肺腺癌患者的临床特征及预后影响因素研究[J].中国全科医学,2016,19(11):1272-1275,4.
