中国全科医学2016，Vol.19Issue(11)：1282-1286,1287,6.DOI:10.3969/j.issn.1007-9572.2016.11.011
弥散张量成像对遗忘型轻度认知障碍诊断和预后评估的价值
Value of Diffusion Tensor Imaging in the Diagnosis and Prognosis of Amnestic Mild Cognitive Impairment
摘要
Abstract
Objective To investigate the value of diffusion tensor imaging(DTI)in the diagnosis and prognosis of amnestic mild cognitive impairment( aMCI). Methods From July 2012 to April 2015,we enrolled 115 patients who were diagnosed with aMCI in Tangshan Gongren Hospital in Hebei Province. According to the domains of cognitive damage,the patients were divided into two groups:single - domain aMCI group( aMCI-s group,n = 60 ) and multiple - domain aMCI group (aMCI-m group,n = 55). When receiving the first treatment and 12 months after discharge from hospital,neuropsychological test and imaging DTI scan were conducted on the patients,and relapse,FA values and ADC values of regions of interest were evaluated. Results When follow - up ended,94 patients were at last included after the exclusion of patients who died,had brain imaging abnormality and got lost for no reason. Among the 94 patients,50 patients were assigned into aMCI-s group,and 44 patients were assigned into aMCI-m group. Among them,24 patients had disease translating into alzheimer's disease 12 months after discharge,and the overall translation rate was 25. 5% . The translation rates of the aMCI-s group and the aMCI-m group were 16. 0% (8 / 50)and 36. 4% (16 / 44),and the two groups were significantly different in AD translation rate(χ2 = 5. 10, P = 0. 02). The aMCI-s group was higher than the aMCI-m group in FA values of corpus callosum knee,splenium of corpus callosum,cingulate fasciculus,and the aMCI-s group was lower than aMCI-m group in ADC value of corpus callosum knee, inferior fronto - occipital fasciculus and superior longitudinal fasciculus Ⅱ(P < 0. 05). The aMCI-s group was higher than the aMCI-s-AD group in the FA values of corpus callosum knee,splenium of corpus callosum and cingulate fasciculus,and the aMCI-s group was lower than the aMCI-s-AD group in the ADC values of corpus callosum knee,splenium of corpus callosum, cingulate fasciculus and superior longitudinal fasciculus Ⅱ(P < 0. 05). The aMCI-m group was higher than the aMCI-m-AD group in corpus callosum knee,cingulate fasciculus and inferior fronto - occipital fasciculus,and the aMCI-m group was lower than the aMCI-m-AD group in ADC value of corpus callosum knee,cingulate fasciculus and superior longitudinal fasciculus Ⅱ(P < 0. 05). The aMCI-s-AD group and the aMCI-m-AD group were not significantly different in the FA values of corpus callosum knee,splenium of corpus callosum,cingulate fasciculus,inferior fronto - occipital fasciculus and superior longitudinal fasciculus Ⅱ(P > 0. 05);the aMCI-s-AD group was lower than the aMCI-m-AD group in ADC values of corpus callosum knee, splenium of corpus callosum,cingulate fasciculus,inferior fronto - occipital fasciculus and superior longitudinal fasciculus Ⅱ(P < 0. 05). Conclusion aMCI-m is more likely to develop into AD than aMCI-s,and DTI could reflect the pathological changes of aMCI and could be used to determine aMCI types and predict its prognosis.关键词
遗忘型轻度认知障碍/阿尔茨海默病/弥散张量成像/诊断/预后Key words
Amnestic mild cognitive impairment/Alzheimer disease/Diffusion tensor imaging/Diagnosis/Prognosis分类
医药卫生引用本文复制引用
李香春,刘江红,王海平,韩德昌,董铮,孙正君,董甜甜,赵志超..弥散张量成像对遗忘型轻度认知障碍诊断和预后评估的价值[J].中国全科医学,2016,19(11):1282-1286,1287,6.基金项目
国家自然科学基金资助项目 （）
