中国全科医学2016，Vol.19Issue(12)：1387-1391,5.DOI:10.3969/j.issn.1007-9572.2016.12.007
重复经颅磁刺激治疗原发性三叉神经痛的疗效及安全性分析
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Treating Idiopathic Trigeminal Neuralgia
摘要
Abstract
Objective To observe the efficacy and safety of repetitive transcranial magnetic stimulation( rTMS)in treating idiopathic trigeminal neuralgia( ITN). Methods From December 2013 to December 2014,the study enrolled 40 patients who were definitely diagnosed with ITN in the Department of Pain Management,Xuanwu Hospital Capital Medical University. Using random number table method,the patients were divided into gabapentin group and rTMS group,20 in each group. General data of the patients were recorded, including gender, age, duration of disease, lesion side and lesion branch. The VAS score and the number of patients with VSA score < 4 were recorded before treatment,in week 2(T1),week 5 (T2),month 1(T3),month 3(T4)and month 6(T5)after treatment. The dosages of gabapentin and the pain remission rate at T1, T2, T3, T4 and T5 were recorded, and adverse reactions such as somnolence and dizziness at T5 were also observed. Results The two groups were not significantly different in gender,age,duration of disease,lesion side and lesion branch( P > 0. 05 ) . One patient in gabapentin group terminated treatment and was excluded from the study due to the ineffectiveness of gabapentin. There was no interaction between treatment method and treatment time for VAS score(P > 0. 05);treatment method had no marked main effect on VAS score(P > 0. 05);treatment time had marked main effect on VAS score(P< 0. 05). The two groups were not significantly different in VAS score at different time points(P > 0. 05). The two groups had lower VAS scores at T1,T2,T3,T4 and T5 than those before treatment(P < 0. 05). Before treatment,there were no patients with VAS score < 4 in the two groups. After treatment,the two groups were not significantly different in the incidence of VAS score< 4 at different time points(P > 0. 05). The two groups of patients were significantly different in the dosage of gabapentin at different time points after treatment(P < 0. 05). The two groups were not significantly different in pain remission rate at different time points after treatment( P > 0. 05). rTMS group was lower than gabapentin group in the incidence rates of dizziness and somnolence after treatment(P < 0. 05). Conclusion rTMS can effectively relieve idiopathic trigeminal neuralgia,and it is a safe and effective method of noninvasive physical therapy.关键词
三叉神经痛/经颅磁刺激/加巴喷丁/治疗结果Key words
Trigeminal neuralgia/Transcranial magnetic stimulation/Gabapentin/Treatment outcome分类
医药卫生引用本文复制引用
李娜,何亮亮,王小平,唐元章,左欣鹭,马玲,杨惠婕,倪家骧..重复经颅磁刺激治疗原发性三叉神经痛的疗效及安全性分析[J].中国全科医学,2016,19(12):1387-1391,5.基金项目
北京市医院管理局医学发展专项---“扬帆”计划（ ZYLX201507）；北京市科学技术委员会项目基金 （）
