中国全科医学2016，Vol.19Issue(12)：1446-1450,5.DOI:10.3969/j.issn.1007-9572.2016.12.018
乌鲁木齐甲状腺癌相关危险因素调查研究
Investigation and Research on the Related Risk Factors for Thyroid Cancer in Urumqi
摘要
Abstract
Objective To investigate the related risk factors of thyroid cancer in Urumqi. Methods The study enrolled 156 thyroid cancer patients(thyroid cancer group)and 158 patients with benign thyroid nodules(benign group)who underwent surgery and were definitely diagnosed as thyroid cancer by pathology in the First Affiliated Hospital of Xinjiang Medical University from March to December 2014. Meanwhile,the study also enrolled 301 healthy adults(normal group)who received physical examination and were determined with normal thyroid gland by B ultrasound in the Second Affiliated Hospital of Xinjiang Medical University. A self - designed questionnaire survey was conducted on the subjects,concerning general information,mode of life and environment,history of ray exposure,history of diseases and family history of diseases,psychological factor,thyroid function,detection of thyroid autoantibodies, history of menstruation of female subjects, history of medication of female subjects,and history of gynecological operation. Multivariate Logistic regression analysis was used to investigate the influencing factors for thyroid cancer. Results The three groups were significantly different in gender composition,age,the usage rate of cosmetics,the usage rate of hair dye,the rate of X - ray examination,the rate of head and neck CT scan,and the serum levels of TSH,TGAb and TPOAb(P < 0. 05). Thyroid cancer group was higher than benign group and normal group in the serum levels of TSH and TGAb(P < 0. 05);thyroid cancer group was higher than normal group in the serum level of TPOAb( P <0. 05);benign group was lower in the serum level of TGAb and was higher in the serum level of TPOAb than normal group(P <0. 05). The three groups were significantly different in the age of menophania,the using rate of contraceptive,and the incidence rate of hysterectomy(P < 0. 05). Multivariate Logistic regression analysis showed that females,head and neck CT scan,and increase in the serum level of TGAb were risk factors for thyroid cancer( P < 0. 05),and hysterectomy was a risk factor for thyroid cancer in females〔 χ2 = 9. 241,P < 0. 05,OR( 95% CI) = 7. 139( 2. 010,25. 350 )〕 . Conclusion Being females,head and neck CT scan and increase in the serum level of TGAb are risk factors for thyroid cancer in Urumqi,and hysterectomy is a risk factor for thyroid cancer in females in Urumqi,which provide references for further study.关键词
甲状腺肿瘤/危险因素/问卷调查/乌鲁木齐Key words
Thyroid neoplasms/Risk factors/Questionnaires/Urumqi分类
医药卫生引用本文复制引用
张虹,陈建华,魏巍,张丽..乌鲁木齐甲状腺癌相关危险因素调查研究[J].中国全科医学,2016,19(12):1446-1450,5.基金项目
新疆维吾尔自治区自然科学基金资助项目 （）
