中国药房2016，Vol.27Issue(10)：1311-1314,4.DOI:10.6039/j.issn.1001-0408.2016.10.05
葛根素及葛根提取物在大鼠体内的药动学研究
Pharmacokinetics Study of Puerarin and Puerarin Lobate Extract in Rats
摘要
Abstract
OBJECTIVE:To investigate the pharmacokinetic characteristics of puerarin and puerarin lobate extract in rats and compare the difference of pharmacokinetic behavior of them. METHODS:24 SD rats were randomly divided into high-dose and low-dose groups of puerarin (300,100 mg/kg) and puerarin lobate extract (equal to 300,100 mg/kg of puerarin). 0.2 ml blood sample were collected from posterior venous plexus of bulbus oculi before intragastric administration and 0.083,0.17,0.33,0.5, 0.67,1,1.5,2,3,4,6,8,10 h after administration,respectively. The pharmacokinetic parameters were calculated by using DAS 3.0 software. RESULTS:Compared with puerarin high-dose group,AUC0-t and cmax of puerarin low-dose group increased sig-nificantly,while CL decreased significantly;MRT0-t of puerarin low-dose group and puerarin lobate extract high-dose and low-dose groups decreased significantly (P<0.01). There was no statistical significance in pharmacokinetic parameters between puerarin lo-bate extract low-dose group and puerarin lobate extract high-dose group (P>0.05). CONCLULSIONS:There is difference in the pharmacokinetic behavior between puerarin and puerarin lobate extract in rats. Some components of puerarin lobate extrats maybe speed up the elimination of puerarin in rats,so as to shorten the average retention time of it.关键词
葛根素/葛根提取物/药动学/大鼠Key words
Puerarin/Puerarin lobate extract/Pharmacokinetics/Rat分类
医药卫生引用本文复制引用
赵洁,苏畅,温德广,李嘉富,胡燕娴,吴芃..葛根素及葛根提取物在大鼠体内的药动学研究[J].中国药房,2016,27(10):1311-1314,4.基金项目
国家自然科学基金资助项目(No.31401499) （No.31401499）
广东省教育厅科研项目(No.2012LYM_0041) （No.2012LYM_0041）
广东省自然科学基金博士启动项目(No.S2012040006229) （No.S2012040006229）
广东省医学科研基金项目(No.B2012214) （No.B2012214）
