中国药房2016，Vol.27Issue(10)：1406-1408,3.DOI:10.6039/j.issn.1001-0408.2016.10.33
染料木素固体分散体的制备及其性质研究
Preparation of Genistein Solid Dispersion and Its Properties Study
孟庆杰 1包琳琳 1潘五九 1王伟明 1王红莉1
作者信息
- 1. 黑龙江省中医药科学院中药所,哈尔滨 150036
- 折叠
摘要
Abstract
OBJECTIVE:To prepare Geinstein (GEN) solid dispersion,and improve the dissolution rate of GEN in vitro. METHODS:Using PVP K30,PEG6000,and PEG4000 as carriers,GEN solid dispersion was prepared by solvent melting meth-od,and its dissolution in vitro was investigated. The structure of the solid dispersion was characterized by FTIR and DSC. RE-SULTS:GEN solid dispersion prepared with PEG4000 as carrier was better than those with other carriers in dissolution,and drug-carrier ratio (1:5) was the best. The results of DSC and FTIR showed that GEN in solid dispersion took amorphous form. CONCLUSIONS:GEN solid dispersion is prepared successfully and significantly improve the dissolution of GEN in vitro.关键词
染料木素/固体分散体/体外溶出度/傅立叶红外光谱法/差示扫描量热法Key words
Geinstein/Solid dispersion/Dissolution in vitro/FTIR/DSC分类
医药卫生引用本文复制引用
孟庆杰,包琳琳,潘五九,王伟明,王红莉..染料木素固体分散体的制备及其性质研究[J].中国药房,2016,27(10):1406-1408,3.
