中国医药科学2016，Vol.6Issue(3)：37-40,4.
AKT1基因多态性与阿尔茨海默病的相关性研究
Study on correlation between AKT1 genetic polymorphism and alzheimer disease
陈忠伟 1赵和丹 2王金龙 2黄通 3田华伟 4王长义 1刘盛元1
作者信息
- 1. 深圳市南山区慢性病防治院慢性病防治科，广东深圳518054
- 2. 浙江省嘉兴市康慈医院临床心理科，浙江嘉兴314599
- 3. 深圳市南山区慢性病防治院南油社康，广东深圳518054
- 4. 广东医学院附属福田医院防保科，广东深圳518033
- 折叠
摘要
Abstract
Objective To study the correlation of insulin signaling pathway between AKT1 genetic polymorphism and alzheimer disease, in order to further understand the effect of AKT1 genetic polymorphism on the susceptibility of alzheimer disease. Methods Patients with alzheimer disease were selected as the research objects in case group, at the same time health physical examinees with matched age and sex were selected as the research objects in control group. To extract DNA, in order to carry out gene sequencing applied by PCR at 6 AKT1 gene locus. Results The differences of AKT1 at rs2498786 gene locus was statically significant compared with case group and control group (P < 0.05). Conclusion Allele C which is the mutant of AKT1 rs2498786 gene locus, could increase the risk of alzheimer disease. AKT could be the susceptible gene of alzheimer disease, AKT1 rs2498786 gene locus could increase the incidence of alzheimer disease, while other AKT gene locus, which has non obviously correlation with alzheimer disease, but not exclude the minor genes, is worthy of further study.关键词
阿尔茨海默病/AKT1/基因多态性Key words
Alzheimer disease/AKT1/Genetic polymorphism分类
医药卫生引用本文复制引用
陈忠伟,赵和丹,王金龙,黄通,田华伟,王长义,刘盛元..AKT1基因多态性与阿尔茨海默病的相关性研究[J].中国医药科学,2016,6(3):37-40,4.
