中国医药科学2016，Vol.6Issue(3)：175-178,4.
ESBLs在大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌中的检出率及耐药情况比较
Comparsion of detection rate and drug resistance of ESBLs in escherichia coli, klebsiella pneumonia and enterobacter cloacae
摘要
Abstract
Objective To analyze and compare detection rate and drug resistance of ESBLs (extended spectrum beta lactamase) in escherichia coli, klebsiella pneumonia and enterobacter cloacae. Methods 116 patients with suppurative cholangitis who were admitted to department of internal medicine of our hospital from June 2011 to September 2011 were selected as clinical research objects. The culture results of escherichia coli, klebsiella pneumonia and enterobacter cloacae of their bile were respectively detected. Drug resistances of ESBLs in every strain were detected by drug sensitive tests. Results Among 154 experimental culture strains, a total of 62 strains produced ESBLs strains and the total detection rate was 40.3%. In 62 strains producing ESBLs strains, escherichia coli was detected in 33 strains (53.2%), enterobacter cloacae was detected in 8 strains (22.2%) and klebsiella pneumonia was detected in 21 strains (37.5%). Detection rate of escherichia coli and klebsiella pneumonia was significantly higher than that of the enterobacter cloacae, x12=22.77. The comparison had statistical significance (P < 0.05). Detection rate of klebsiella pneumonia was significantly higher than that of the enterobacter cloacae, x22=7.61. The comparison had statistical significance (P < 0.05). In all kinds of specimens, detection rate of klebsiella pneumonia producing ESBLs was the highest (85.7%) in bile culture results of bile duct calculi cases. In malignant biliary obstruction cases, detection rates of escherichia coli, and enterobacter cloacae producing ESBLs were higher. Enterobacter cloacae, escherichia coli and klebsiella pneumonia producing ESBLs were all resistant to amoxicillin. And the rate of drug resistance was 100%. 3 strains were of high resistance to cephalosporin antibiotics and 3 strains were of low resistance to carbopenems. Rate of drug resistance of enterobacter cloacae producing ESBLs were lower than that of escherichia coli and klebsiella pneumonia. The difference was most significant especially in gentamicin, ciprofloxacin and cephalosporin medicine. Conclusion For infectious disease caused by strains producing ESBLs, properly choosing antibiotics in combination with drug sensitive test is the key to delay the occurrence of bacteria resistance and an important guarantee of clinically rational medication.关键词
ESBLs(超广谱内酰胺酶)/大肠埃希菌/阴沟肠杆菌/肺炎克雷伯菌/检出率/耐药性Key words
ESBLs(extended spectrum beta lactamase)/Escherichia coli/Enterobacter cloacae/Klebsiella pneumonia/Detection rate/Drug resistance分类
医药卫生引用本文复制引用
唐景云,秦晓林..ESBLs在大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌中的检出率及耐药情况比较[J].中国医药科学,2016,6(3):175-178,4.基金项目
广东省深圳市坪山新区卫生系统科研资助项目（201428）。 （）
