中国医药科学2016，Vol.6Issue(4)：18-20,3.
肺间质纤维化合并肺气肿患者血清VEGF、TGF-β1、IGF-I水平及临床意义
Clinical significance of serum levels of VEGF,TGF-β1 and IGF-I in patients with pulmonary interstitial fibrosis and emphysema
摘要
Abstract
Objective To discuss clinical significance of serum levels of VEGF,TGF-β1 and IGF-I in patients with pulmonary interstitial fibrosis and emphysema.Clinical data of cases with CPFE,IPF and emphysema from Jan 2013 to Jun 2015 were respectively analyzed.34 cases with CPFE were group A,78 cases with IPF were group B,and 43 cases with emphysema were group C.VEGF、TGF-β1、IGF-I levels of three groups were compared.Relationship of smoking with VEGF、TGF-β1、IGF-I levels in patients with CPFE was analyzed.Results VEGF of group B was higher than group C (P<0.05);TGF-β1 levels of group A and group B were higher than group C (P<0.05);IGF-I levels of group A and group B were higher than group C (P<0.05).In patients with CPFE,VEGF level of the smoker was higher than non-smoker(P<0.05);But TGF-β1 and IGF-I levels between the smoker and non-smoker showed no significant difference(P>0.05).Conclusion The decrease of VEGF,the increase of TGF-β1 and the increase of IGF-I participated in the occurrence of CPFE.关键词
肺间质纤维化合并肺气肿综合征/特发性肺间质纤维化/肺气肿/转化生长因子-β1/血管内皮生长因子/胰岛素样生长因子ⅠKey words
CPFE/IPF/Emphysema/TGF-β1/VEGF/IGF-I分类
医药卫生引用本文复制引用
秦文婧,梁宇,齐红松..肺间质纤维化合并肺气肿患者血清VEGF、TGF-β1、IGF-I水平及临床意义[J].中国医药科学,2016,6(4):18-20,3.基金项目
河南省开封市科技社会发展攻关计划项目（1403125）。 （）
