摘要
Abstract
Objective To investigate the clinical effect of intermittent antiandrogen therapy in the treatment of prostate disease.Methods According to treatment order,58 patients with advanced prostate cancer who were in our hospital form January 2012 to March 2015 were divided into observation group and control group.The control group was treated with surgical castration combined with continuous antiandrogen therapy.The observation group was treated with drug castration combined with intermittent antiandrogen therapy.Then,therapy effects,prostate specific antigen (PSA) levels, Gleason scores,and adverse reactions of two groups after 6 months' treatment were compared.Results The total effective rate of the observation group was higher than that of the control group (96.55% vs 75.85%,P<0.05). The serum PSA level and Gleason score in the observation group were less than those in the control group. Comparison of values among two groups were statistically significant (P<0.05).The incidence of hot flash, breast swelling, diarrhea,anemia, and osteoporosis in the observation group during treatment was lower than that of the control group (17.24% vs 48.28%,10.34% vs 44.83%,17.24% vs 65.52%,6.90% vs 34.48%,10.34% vs 41.38%,P<0.05). Conclusion Intermittent antiandrogen therapy for patients with prostate cancer can obtain much better treatment effect and safety.关键词
间歇性/抗雄激素/前列腺癌/前列腺特异性抗原Key words
Intermittent/Antiandrogen/Prostatic cancer/Prostate specific antigen分类
医药卫生
