中国卒中杂志2016，Vol.11Issue(4)：288-295,8.DOI:10.3969/j.issn.1673-5765.2016.04.009
右向左分流患者的脑血流自动调节受损：偏头痛和隐源性卒中的潜在机制
Compromised Dynamic Cerebral Autoregulation in Patients with a Right-to-Left Shunt：a Potential Mechanism of Migraine and Cryptogenic Stroke
郭珍妮 1邢英琦 2刘嘉 3王爽 1闫硕 1靳航 1杨弋 1吕珊(译) 1郭雨竹(译)1
作者信息
- 1. 1130021 长春吉林大学第一医院神经内科
- 2. 吉林大学第一医院神经血管超声中心
- 3. 中国科学院深圳先进技术研究院
- 折叠
摘要
Abstract
Objective The relationship between right-to-left shunts (RLS) and migraine and cryptogenic stroke is not well understood. In this study, we investigated whether RLS are associated with impairment of dynamic cerebral autoregulation (dCA), which may play a role in migraine and cryptogenic stroke. <br> Methods Sixty-six migraineurs were enrolled in the study, including 36 non-RLS patients and 30 RLS patients. Non-invasive continuous cerebral blood flow velocity and arterial blood pressure were recorded simultaneously from each patient by using transcranial Doppler and servo-controlled plethysmograph, respectively. Transfer function analysis was applied to derive autoregulatory parameters of gain, phase difference (PD), and autoregulation index. <br> Results The PD in migraineurs with RLS was 50.6˚±22.9˚, which was signiifcantly lower than that observed in the non-RLS group (67.2˚±18.2˚,P<0.001). The PD in the large RLS group (45.4˚±22.6˚) was signiifcantly lower than that of the small RLS group (64.9˚±17.1˚,P<0.01) and non-RLS group (P<0.001); however, the PD in the small RLS group was similar to that of the non-RLS group. The PD in the permanent group (48.8˚±19.9˚) was similar to that of the latent group (52.6˚±26.1˚), and both were signiifcantly lower than that of the non-RLS group (P<0.05). The autoregulation index results were similar to the PD ifndings. <br> Conclusion dCA is impaired in migraineurs with large RLS, and this may represent a potential mechanism linking RLS, migraine, and cryptogenic stroke.关键词
脑血流自动调节/偏头痛/右向左分流/隐源性卒中Key words
Dynamic cerebral autoregulation/Migraineurs/Right-to-left shunts/Cryptogenic stroke引用本文复制引用
郭珍妮,邢英琦,刘嘉,王爽,闫硕,靳航,杨弋,吕珊(译),郭雨竹(译)..右向左分流患者的脑血流自动调节受损：偏头痛和隐源性卒中的潜在机制[J].中国卒中杂志,2016,11(4):288-295,8.
