南方医科大学学报2016，Vol.36Issue(3)：303-308,6.DOI:10.3969/j.issn.1673-4254.2016.03.02
猪抗人淋巴细胞球蛋白与兔抗人胸腺细胞球蛋白治疗重型再生障碍性贫血的疗效比较
Therapeutic effects of porcine versus rabbit antithymocyte globulins for treatment of severe aplastic anemia
摘要
Abstract
Objective To compare the efficacy of porcine and rabbit antithymocyte globulins (ATG) in the treatment of severe aplastic anemia (SAA). Methods We reviewed the clinical data of 43 SAA patients receiving porcine ALG treatment and 32 patients receiving rabbit ATG treatment between 2004 and 2013 in our hospital. The overall response rates of the patients at 6 month were compared, and the patients' survival in the two groups was analyzed using Kaplan-Meier survival curves. Results The overall response rates at 6 months was significantly higher in porcine ALG group than in rabbit ATG group (79.07% vs 56.25%, P=0.034). The 5-year overall survival was also higher in porcine ALG group than in rabbit ATG group, but this difference was not statistically significant (86.047% vs 72.878%, P=0.190). Conclusions Porcine ALG is superior over rabbit ATG in terms of hematological response but is comparable with rabbit ATG in view of the patients' survival and safety.关键词
猪抗人淋巴细胞球蛋白/兔抗人胸腺细胞球蛋白/再生障碍性贫血Key words
porcine antilymphocyte globulin/rabbit antithymocyte globulin/aplastic anemia引用本文复制引用
杨楠,马肖容,张卉,曹星梅,陈银霞,何爱丽,刘捷,赵万红,张王刚..猪抗人淋巴细胞球蛋白与兔抗人胸腺细胞球蛋白治疗重型再生障碍性贫血的疗效比较[J].南方医科大学学报,2016,36(3):303-308,6.基金项目
国家自然科学基金（081718110232）；2013年陕西省科学技术研究发展计划项目（2013K12-06-03）Supported by National Natural Science Foundation of China (081718110232) （081718110232）
