南方医科大学学报2016，Vol.36Issue(3)：361-364,4.DOI:10.3969/j.issn.1673-4254.2016.03.12
YY1在胰岛素瘤中的表达及意义
Expression of YY 1 protein in human insulinoma and its clinical implication
摘要
Abstract
Objective To investigate the expression of Yin Yang 1 (YY1) protein in human insulinoma and explore its clinical significance. Methods Nineteen pancreatic neuroendocrine tumor tissue were collected from patients treated in Nanfang Hospital between 2000 and 2014. The protein expression of YY1 in benign and malignant insulinoma tissues were detected by immunohistochemistry. Results Positive expression for YY1 protein was detected in both benign and malignant tumor tissues, but the malignant tissues had a significantly greater intensity of YY1 expression than the benign tissues (P=0.042). The intensity of YY1 expression was positively correlated with the nature of the tumor, and the insulinomas with high expressions of YY1 had significantly greater malignant potentials (P=0.037). Conclusion The high expression of YY1 protein is associated with the development of insulinima. YY1 may serve as a new tumor marker for detecting the malignant transformation of insulinoma.关键词
YY1/胰岛素瘤/胰岛细胞瘤/胰腺神经内分泌肿瘤Key words
YY 1/insulinoma/islet cell tumor/pancreatic neuroendocrine tumor引用本文复制引用
李雯霞,黄业恩,石晓欣,林佩欣,邹振宁,张耀忠,申洪..YY1在胰岛素瘤中的表达及意义[J].南方医科大学学报,2016,36(3):361-364,4.基金项目
国家自然科学基金（81271729）Supported by National Natural Science Foundation of China (81271729) （81271729）
