南方医科大学学报2016，Vol.36Issue(3)：381-385,5.DOI:10.3969/j.issn.1673-4254.2016.03.16
长方案控制性超促排卵过程中黄体生成素水平对多囊卵巢综合征患者IVF-ET结局的影响
Effect of luteinizing hormone variation on clinical outcomes in patients with polycystic ovarian syndrome undergoing in vitro fertilization-embryo transfer using standard long protocol
摘要
Abstract
Objective To evaluate the effect of serum luteinizing hormone (LH) variation on clinical outcomes in patients with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis was conducted in 314 patients with PCOS undergoing their first IVF cycle using standard long protocol. On the basis of LH concentrations on early-, mid-and late-follicular phase, the patients were divided into decreased LH (LH ratio≤1, group A) and increased LH (group B, LH ratio>1) groups in early-to mid-follicular phase, decreased LH (group C) and increased LH (group D) groups in mid-to late-follicular phase, and decreased LH (group E) and increased LH (group F, LH ratio>1) in early-to late-follicular phase. The clinical outcomes were compared between groups A and B, groups C and D, and between groups E and F. Results No significant differences were found in the clinical outcomes between group A and B (P>0.05). The number of oocytes retrieved and the early abortion rate were significantly lower, but the normal fertilization rate, implantation rate, clinical pregnancy rate and ongoing pregnancy rate were significantly higher in group D than in group C (P<0.05). In group F, the early abortion rate was significantly lower and the ongoing pregnancy rate was significantly higher than those in group E (P<0.05), and no significant differences were found in other clinical outcomes between the two groups (P>0.05). Conclusion An increase in LH level from early- or mid- to late-follicular phase has a positive effect on the clinical outcomes, but this LH variation in early-to mid-follicular phase does not affect the clinical outcomes.关键词
黄体生成素变化趋势/长方案/多囊卵巢综合征/体外授精-胚胎移植Key words
variation of luteinizing hormone/long protocol/polycystic ovarian syndrome/in vitro fertilization-embryo transfer引用本文复制引用
阎梦,华芮,周瑶,聂庆文,李红..长方案控制性超促排卵过程中黄体生成素水平对多囊卵巢综合征患者IVF-ET结局的影响[J].南方医科大学学报,2016,36(3):381-385,5.基金项目
国家科技支撑计划（2013BAI12B00）Supported by National Plan for Science and Technology Research (2013BAI12B00) （2013BAI12B00）
