国际医药卫生导报2016，Vol.22Issue(8)：1080-1082,3.DOI:10.3760/cma.j.issn.1007-1245.2016.08.013
辅助化疗、内分泌治疗对绝经后乳腺癌患者骨密度的影响
Influence of adjuvant chemotherapy and endocrine therapy on bone density in postmenopausal patients with breast cancer
摘要
Abstract
Objective To study the influence of adjuvant chemotherapy and endocrine therapy on the bone density in postmenopausal patients with breast cancer.Methods 50 postmenopausal patients diagnosed with breast cancer at our hospital from June,2013 to October,2015 were collected.Their bone density of lumbar 2-4 and right femoral neck was measured by dual-energy X-ray absorptiometry after surgery,before conventional chemotherapy,after conventional chemotherapy,and after 1 year of endocrine AI therapy.Paired t test was used to compare the difference in bone density of lumbar and femoral neck between before and after conventional chemotherapy and between after conventional chemotherapy and after 1 year of endocrine AI therapy.Results The bone density of lumbar and femoral neck was significantly lower after than before conventional chemotherapy,with a statistical difference,and was significantly lower after 1 year of endocrine AI therapy than after conventional chemotherapy,with a statistical difference.Conclusions Adjuvant chemotherapy and endocrine therapy for postmenopausal patients with breast cancer can affect their bone metabolism and decrease their bone density.It is necessary to take early cautions to prevent bone loss and osteoporosis.关键词
乳腺癌/化疗/内分泌治疗/骨密度Key words
Breast cancer/Chemotherapy/Endocrine therapy/Bone density引用本文复制引用
连志标,李幸运,吴泽炀,方志潮..辅助化疗、内分泌治疗对绝经后乳腺癌患者骨密度的影响[J].国际医药卫生导报,2016,22(8):1080-1082,3.
