摘要
Abstract
Objective To investigate the clinical effect of mosapride combined with omeprazole in the treatment of reflux esophagitis after surgery for esophageal carcinoma.Methods 84 patients with reflux esophagitis after surgery for esophageal cancer were randomly divided into an observation group and a control group.The observation group were treated with omeprazole (20mg,bid) and mosapride (5 mg,tid) and the control group with mosapride (5 mg,rid) for 2 months.Before and after the treatment,both groups were checked with gastroscope and scored.Results The heartburn,acid regurgitation,reflux,chest pain,and other clinical symptoms were significantly better and the symptom scores were lower after 2 months' treatment than before the treatment in the observation group,with statistical differences (t=4.821,P＜0.05).After the treatment,the symptom score was significantly lower in the observation group than in the control group,with a statistical difference (t=4.973,P ＜ 0.05);and each clinical symptom had been significantly improved.After 2 months' treatment,the clinical symptoms completely disappeared in 12 cases and almost disappeared in 23 cases in the observation group,with a total symptom remission rate of 83.3％,and 8 cases and 16 cases in the control group,with a total symptom remission rate of 57.1％.There was a statistical difference in total remission rate between these two groups (x 2=5.454,P ＜ 0.05).After treatment,the gastroscopic results showed that 24 cases were cured and 13 effective in the observation group,with a total efficacy of 88.1％,and 18 cured and 5 effective in the control group,with a total efficacy of 54.8％,with a statistical difference (x 2=5.312,P ＜ 0.05).Conclusions Mosapride combined with omeprazole in the treatment of reflux esophagitis after surgery for esophageal cancer is effective and has no serious adverse reactions.关键词
莫沙必利/奥美拉唑/反流性食管炎/食管癌术后Key words
Mosapride/Omeprazole/Reflux esophagitis/After surgery for esophageal cancer
