国际医药卫生导报2016，Vol.22Issue(8)：1150-1152,1157,4.DOI:10.3760/cma.j.issn.1007-1245.2016.08.037
硫酸镁防治SAH后脑血管痉挛及脑组织损伤的效果及机制分析
Effect and mechanism of magnesium sulfate in prevention and treatment of cerebral angiospasm and brain tissue injury after SAH
吴松伟1
作者信息
- 1. 474250 河南省镇平县人民医院神经内科
- 折叠
摘要
Abstract
Objective To study the effect and mechanism of magnesium sulfate in the prevention and treatment of cerebral angiospasm and brain tissue injury after subarachnoid hemorrhage (SAH).Methods 50 patients with SAH who were treated at our hospital from May,2012 and November,2014 were selected as study objects and were randomized into an observation group and a control group,25 cases for each group.The observation group were treated with magnesium sulfate and the control group routine therapy.After the treatment,the effect of magnesium sulfate in the prevention and treatment of cerebral angiospasm and brain tissue injury after SAH were observed and its mechanism was analyzed.Results The total effective rate and Glasgow Coma Scale (GCS) score were significantly in the observation group higher than in the control group [76％ vs.48％ and (12.78±2.05) vs.(10.73±2.36),P ＜ 0.05].After the treatment,the incidence of delayed cerebral vasospasm (DCVs) and MCA blood flow velocity,were significantly lower in the observation group than in the control group [4％ vs.24％ and (84.91±17.50) cm/s vs.(102.87±15.72) cm/s,P ＜ 0.05].Conclusions The effect of magnesium sulfate in the prevention and treatment of cerebral angiospasm and brain tissue injury after SAH is significant.Its specific mechanism relates to the competitive antagonism of Mg2+ against Ca2+ and the inhibition of excitatory amino acids,free radicals,and other toxic compounds.关键词
硫酸镁/SAH/脑血管痉挛/脑组织损伤Key words
Magnesium sulfate/SAH/Cerebral angiospasm/Brain tissue injury引用本文复制引用
吴松伟..硫酸镁防治SAH后脑血管痉挛及脑组织损伤的效果及机制分析[J].国际医药卫生导报,2016,22(8):1150-1152,1157,4.
