国际妇产科学杂志2016，Vol.43Issue(2)：140-144,5.
人源性卵巢癌异体移植模型的研究进展
Updates of Patient Derived Xenografts Model in Ovarian Tumors
摘要
Abstract
Ovarian cancer has the highest motality among the female reproductive malignancies. The underling mechanism is still unknown, and the prognosis has not been improved significantly. To establish an ideal preclinical model is in favor of the study of recurrence and metastasis in ovarian cancer. Recently, the development of patient derived xenografts model gives us a new platform for preclinical study. Gradually it has been used in the study of breast cancer, lung cancer and colon cancer, where it is proved to be useful. Much less studies on the use of patient derived xenografts model in ovarian cancer has been reported and data was shown promising. Based on the existing literature retrieval, this model could better copy the biological characteristics of the primary tumor and keep the heterogeneity of primary tumor. But there were still some problems need to be solved in the application of it, such as the different tumor take rate, the limited tumor resources and the lack of effective quality control standards. Here this review aims to address the application status, existing problems and application prospects of this model.关键词
卵巢肿瘤/模型,动物/动物实验/肿瘤移植/移植,异种Key words
Ovarian neoplasms/Models,animal/Animal experimentation/Neoplasm transplantation/Transplantation, heterologous引用本文复制引用
吴建发,易晓芳..人源性卵巢癌异体移植模型的研究进展[J].国际妇产科学杂志,2016,43(2):140-144,5.基金项目
上海市科学技术委员会科研计划项目 （）
