国际妇产科学杂志2016，Vol.43Issue(2)：169-173,5.
A PC基因的DNA甲基化与卵巢癌关系荟萃分析
A Meta-analysis of DNA-Methylated Gene APC and Ovarian Cancer
摘要
Abstract
Objective:To investigate the role of A PC gene inactivation in the occurrence and development of ovarian cancer. Methods:Databases such as PubMed, EMBase, Web of Science, and CNKI data were searched. Related literatures were published from January 1, 2000 to December 31, 2014. Only randomized controlled trials were included. The quality of the included studies were assessed by Newcastle-Ottawa Scale(NOS). Stata 11.0 software was used for statistical analysis such as OR value,heterogeneity and publication bias. Results:Nine studies, with 641 ovarian cancer patients and 377 controls were included in the Meta-analysis. Statistical results shows that the pooled odds ratio was 6.19 (95%CI:4.08-9.41, P=0.000) in the case group versus the control group under fix effects model. The pooled odds ratio was 5.88 (95%CI:3.662-9.450, P=0.000) in the cancer group versus the normal group under fix effects model. The pooled odds ratio was 6.99 (95%CI:3.12-15.64, P=0.000) in the cancer group versus the benign tumor group under fix effects model. Conclusions:This analysis suggests that A PC gene methylation had an association with ovarian cancer.关键词
卵巢肿瘤/基因,APC/DNA甲基化/Meta分析Key words
Ovarian neoplasms/Genes,APC/DNA methylation/Meta-analysis引用本文复制引用
闫冰冰,李力..A PC基因的DNA甲基化与卵巢癌关系荟萃分析[J].国际妇产科学杂志,2016,43(2):169-173,5.基金项目
教育部高校博士学科点专项基金（20124503110003）；广西科学研究与技术开发计划项目 （）
