国际妇产科学杂志2016，Vol.43Issue(2)：194-198,5.
HMGB1对子宫内膜异位症新生血管生成的潜在作用
Potential Role of HMGB1 in Angiogenesis of Endometriosis
摘要
Abstract
Angiogenesis is one of the important pathogenesis of endometriosis. Abnormal neovascularization in endometriosis promotes the proliferation, infiltration and migration of ectopic endometrial cells. High mobility group box 1 protein (HMGB1), as an important pro-inflammatory factor, is recently proved to contribute to angiogenesis in different tumors. HMGB1 can promote neoangiogenesis by acting directly on endothelial cells or indirect effects on endothelial cells by vascular endothelial growth factor (VEGF), which is synthesized and secreted by NF-κB-activating macrophages. In addition, HMGB1 also promotes proliferation and migration of endothelial cells by up-regulating the expression of fibroblast growth factor (FGF) and enhancing the activity as well as the affinity of integrins, promotes the secretion of platelet-derived growth factor (PDGF) and then recruits pericytes and smooth muscle cells, activating the formation of vascular tubular structure. Activates the secretion of TGF-βfrom endothelial cells, finally promoting the maturation of vascular network. Here we review the potential mechanism of HMGB1 underlying the influence of pro-angiogenesis in endometriosis in detail, thus providing a new therapeutic target for endometriosis.关键词
HMGB1蛋白质/子宫内膜异位症/新生血管化,病理性Key words
HMGB1 protein/Endometriosis/Neovascularization,pathologic引用本文复制引用
吴锦杰,梁炎春,姚书忠..HMGB1对子宫内膜异位症新生血管生成的潜在作用[J].国际妇产科学杂志,2016,43(2):194-198,5.基金项目
中山大学医科2015年暑期学生科研暨科研小组活动项目 （）
