摘要
Abstract
Objective To explore effect of the lactoferrin on anemia and recurrent respiratory tract infection in preterm infants born between 34 to 36 weeks.Methods A total of 80 cases of preterm infants born between 34 to 36 weeks, whose outcomes were followed up, were randomly divided into two groups.All those preterm infants received treatment at child health clinic of Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region.Infants in control group started to take iron dextran dispersible tablets when they were one month old.At the same time, infants in treatment group received lactoferrin capsules.When all the infants were at 1 year corrected age, incidence rate of recurrent respiratory tract infection, the usage of antibiotics, and post-infectious hospitalization rate in infants of both groups were calculated. In addition, changes in hemoglobin (Hb) , hematocrit (Hct) , ferritin, serum iron, T cell subest and immunoglobulin were monitored before and after treatment.Results There was no statistically significant difference in Hb and Hct between two groups after treatment (t value was 1.78 and 0.75, respectively, both P>0.05).However, the levels of ferritin (40.61 ±3.12 ng/mL) and serum iron (12.34 ±2.11μmol/L) were significantly higher in the treatment group than in the control group (t value was 2.51 and 2.06, respectively, both P<0.05).Compared with the control group, the treatment group witnessed more significant increase in CD4, CD8, NK cells, T lymphocyte subsets and serum IgA (t value was 4.73, 4.22, 7.04, 2.92 and 3.95, respectively, all P<0.05).Moreover, the incidence rate of recurrent respiratory tract infection (20%), usage of antibiotics (17.5%) and post-infectious hospitalization rate (12.5%) were lower in the treatment group than in the control group (χ2 value was 4.71, 4.01 and 4.58, respectively, all P<0.05).Conclusion Lactoferrin can effectively prevent late preterm infants from anemia and reduce the incidence rate of recurrent respiratory tract infection and post-infectious hospitalization rate.In addition, lactoferrin can help to reduce the usage of antibiotics and strengthen immunologic functions.关键词
早产儿/贫血/反复呼吸道感染/乳铁蛋白Key words
preterm infant/anemia/recurrent respiratory tract infection/lactoferrin分类
医药卫生
