中国妇幼健康研究2016，Vol.27Issue(4)：442-444,3.DOI:10.3969/j.issn.1673-5293.2016.04.009
联合检测血清CT-IgG60及CHSP60在筛查输卵管不孕中的价值
Clinical value of joint detection of serum CT-IgG60 and CHSP60 in the screening for tubal infertility
摘要
Abstract
Objective To investigate the clinical value of joint detection of serum Chlamydia trachomatis IgG (CTIgG) and Chlamydia heat shock protein 60 (CHSP60) in the preliminary screening for tubal infertility.Methods Serums were collected from 33 cases of patients with tubal infertility (study group) and 15 cases of infertile patients with normal pelvic cavity and non-tubal factors (control group) .All those patients were diagnosed at the Second Xiangya Hospital of Central South University or gynecology department of Hunan Prevention and Treatment Center for Occupational Diseases by laparoscope from October 2011 to May 2012.Enzyme-linked Immunosorbent Assay was used to detect CTIgG and CHSP60.Single or joint detection of CTIgG and CHSP60 were carried out to explore the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and Youden index of the screening for tubal infertility.Results The positive rate of CTIgG in the study group and control group was 57.58%(19/33) and 6.67%(1/15) , respectively.In addition, the positive rate of CHSP60 in the study group and control group was 54.55%(18/33) and 6.67%(1/15), respectively.Thus, the positive rate of CTIgG and CHSP60 in the study group was higher than that of the control group, and the difference was statistically significant (χ2 value was 10.996 and 9.885, respectively, both P<0.05).The sensitivity and specificity of CTIgG in the study group was 57.58%and 93.3%, respectively. Besides, the sensitivity and specificity of CHSP60 in the study group was 54.55%and 93.3%, respectively.The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and Youden index of joint detection was 80.72%, 87.04%, 6.23, 0.07 and 0.68, respectively.Conclusion Joint detection of serum CTIgG and CHSP60 is a relatively good and non-invasive serological indicator in the preliminary screening for tubal infertility, especially for the exclusion of infertility of non-tubal factors.关键词
沙眼衣原体免疫球蛋白/衣原体热休克蛋白60/输卵管不孕/腹腔镜Key words
Chlamydia trachomatis immunoglobulin (CTIgG)/Chlamydia heat shock protein 60 (CHSP60)/tubal infertility/laparoscope分类
医药卫生引用本文复制引用
田红菊,陈建林,施晓波,周妮..联合检测血清CT-IgG60及CHSP60在筛查输卵管不孕中的价值[J].中国妇幼健康研究,2016,27(4):442-444,3.基金项目
湖南省自然科学基金资助项目(2015JJ4071) （2015JJ4071）
