国际病理科学与临床杂志2016，Vol.36Issue(3)：247-251,5.DOI:10.3978/j.issn.2095-6959.2016.03.007
热疗联合FOLFOX4方案治疗晚期原发性肝癌的临床观察
Clinical observation of thermal therapy in combination with FOLFOX4 regimen in primary hepatocarcinoma
刘海波 1曹明 1胡大勇 1黄文琴1
作者信息
- 1. 勉县医院肿瘤科，陕西 勉县 724200
- 折叠
摘要
Abstract
Objective:To evaluate the efficacy and taxicity of thermal therapy in combination with FOLFOX4 regimen in primary hepatocarcinoma.Methods: A total of 126 patients with advanced primary hepatocarcinoma were treated with L-OHP 100 mg/m2, ivgtt (day 1); CF 200 mg/m2, ivgtt (day 1~5); 5-Fu 400 mg/m2, ivgtt (day 1~5). The patients in treatment group received additional thermal therapy, but control group not. hTe effcacy and toxicitis were respectively evaluated according to RECIST criteria and NCL CTC.Results:A total of 66 patients were available for the objective effciency and toxicity, including 7 with complete response (CR), 13 with partial response (PR), 18 with stable disease (SD). hTe 60 patients were involved in the control group, including 2 with CR, 6 with PR, 14 with SD. The median overall survive was 7.2 months in the treatment group and 6.5 months in control group. hTe main toxicities were granulocytopenia, nausea, vomiting, and mmild neurotoxicity.Conclusion:hTe thermal therapy in combination with FOLFOX4 regimen was effective and safe for patients with advanced primary hepatocarcinoma.关键词
原发性肝癌/化学治疗/热疗法Key words
primary hepatocarcinoma/chemotherapy/thermotherapy引用本文复制引用
刘海波,曹明,胡大勇,黄文琴..热疗联合FOLFOX4方案治疗晚期原发性肝癌的临床观察[J].国际病理科学与临床杂志,2016,36(3):247-251,5.
