临床与病理杂志2016，Vol.36Issue(3)：308-313,6.DOI:10.3978/j.issn.2095-6959.2016.03.018
线粒体功能障碍与阿尔茨海默病关系的研究进展
Research progress of the relationship between mitochondrial dysfunction and Alzheimer’s disease
摘要
Abstract
Alzheimer’s disease is the most common type of dementia, and its pathogenesis is very complex. Mitochondria are dynamic organelles that participate in the regulation of energy metabolism, oxidative stress, cell apoptosis and so on. Beta amyloid protein, Tau and oxidative stress can lead to mitochondrial dysfunction, which can result in synaptic damage, nerve cell apoptosis and promote the progress of Alzheimer’s disease.关键词
线粒体/阿尔茨海默病/氧化应激/β淀粉样蛋白/TauKey words
mitochondria/Alzheimer’s disease/oxidative stress/beta amyloid protein/Tau引用本文复制引用
曹玉成,宋炜熙,王哲..线粒体功能障碍与阿尔茨海默病关系的研究进展[J].临床与病理杂志,2016,36(3):308-313,6.基金项目
国家自然科学基金资助项目(81373705)；湖南省自然科学基金资助项目(13JJ3030)。@@@@This work was supported by National Natural Science Foundation of China (81373705) （81373705）
Natural Science Foundation of Hunan Province (13JJ3030), P. R. China （13JJ3030）
