临床与病理杂志2016，Vol.36Issue(3)：342-347,6.DOI:10.3978/j.issn.2095-6959.2016.03.024
AGEs介导的糖尿病肾损伤机制及二甲双胍的干预作用
Mechanisms of diabetic nephropathy mediated by AGEs and effects of metformin intervention
摘要
Abstract
Diabetic nephropathy (DN) is one of the common chronic microvascular complications of diabetes mellitus (DM). High expression of advanced glycation products (AGEs) during high glucose conditions involved in the occurrence and development of diabetic nephropathy by inducing renal oxidative stress and endoplasmic reticulum stress (ERS). Metformin is one of the drugs used widely for the treatment of type 2 diabetes mellitus. Many evidences demonstrated that metformin not only can control glycemic, but also inhibit the production of AGEs and oxidative stress. Studying the relationship between AGES and diabetic nephropathy can help further understand the pathogenesis of diabetic nephropathy, and make some important guideline for DN treatment.关键词
糖尿病肾病/糖基化终末产物/氧化应激/内质网应激/二甲双胍Key words
diabetic nephropathy/advanced glycation end products/oxidative stress/endopla smic reticulum stress/metformin引用本文复制引用
李业琼,叶山东..AGEs介导的糖尿病肾损伤机制及二甲双胍的干预作用[J].临床与病理杂志,2016,36(3):342-347,6.基金项目
安徽省自然科学基金(11040606M159)。@@@@This work was supported by Natural Science Foundation of Anhui Province (11040606M159), P. R. China （11040606M159）
