神经损伤与功能重建2016，Vol.11Issue(2)：95-98,4.DOI:10.16780/j.cnki.sjssgncj.2016.02.001
人参皂苷 Rg1对局灶性脑缺血再灌注大鼠的神经保护作用
Neuroprotective Effect of Ginsenoside Rg1 on Focal Cerebral Ischemia-Reperfusion Rats
摘要
Abstract
Objective: To explore the neuroprotective effect of Ginsenoside Rg1 on focal cerebral ischemia-reper-fusion (FCIR) rats. Methods: Totally 72 rats were randomly divided into 6 groups: sham-operation group, control group, Nimodipine group (10.8 mg/kg), Ginsenoside Rg1 low dose group (10 mg/kg), Ginsenoside Rg1 medium dose group (20 mg/kg), and Ginsenoside Rg1 high dose group (40 mg/kg), with 12 rats in each group. The FCIR model was performed with the method of middle cerebral artery occlusion. The sham-operation and control groups were given normal saline, while other groups received corresponding medication by intragastric administration for 14 days. After the treatment, the neural function was assessed, and numbers of positive cells representing tissue in-hibitors of metalloproteinases1 (TIMP1) and ratio of cell apoptosis in the parietal and temporal cortex were detect-ed. Results: Compared with the control group, scores of neural function were decreased remarkably in all Gin-senoside Rg1 groups and Nimodipine group(P<0.05). Numbers of TIMP1-positive cells in the parietal and temporal cortex of the control group was significantly higher than that in the sham-operation group (P<0.01). Compared with the control group, numbers of TIMP1-positive cells increased remarkably in all theGinsenoside Rg1 groups and Ni-modipine group (P<0.05 or <0.01). Ratio of cell apoptosis in parietal and temporal cortex of the control group was significantly higher than that in the sham-operation group (P<0.01). Compared with the control group, ratio of cell apoptosis was decreased remarkably in all the Ginsenoside Rg1 groups and Nimodipine group (P<0.05 or <0.01). Conclusion: Ginsenoside Rg1 may promote the expression of TIMP1, thus decrease the ratio of cell apoptosis and finally improve the neural function in FCIR rats.关键词
人参皂苷Rg1/局灶性脑缺血再灌注/基质金属蛋白酶抑制因子1/细胞凋亡Key words
ginsenoside Rg1/focal cerebral ischemia-reperfusion/tissue inhibitors of metalloproteinase 1 (TIMP1)/cell apoptosis分类
医药卫生引用本文复制引用
李亮,邓文祥,何军锋,曾光,刘旺华,李花,黄惠勇..人参皂苷 Rg1对局灶性脑缺血再灌注大鼠的神经保护作用[J].神经损伤与功能重建,2016,11(2):95-98,4.基金项目
国家自然科学基金（No.81302899，81373551，81202632）；湖南省教育厅科学研究项目重点项目（No.60010408）；教育部博士点基金（No.20124323120003）；湖南省自然科学基金（No.13JJ3097）；湖南省中医药科研计划项目 （）
