神经损伤与功能重建2016，Vol.11Issue(2)：138-140,3.DOI:10.16780/j.cnki.sjssgncj.2016.02.014
舍曲林联合氨磺必利治疗难治性强迫症的临床研究
Effects of Sertraline Combined with Amisulpride Treatment on Refractory Obsessive Compul-sive Disorder
摘要
Abstract
Objective: To explore the efficacy and safety of sertraline combined with amisulpride treatment on re-fractory obsessive-compulsive disorder (OCD). Methods: Forty-five OCD patientswere randomly divided into groups control (n=23) and experimental (n=22). The control group was given sertraline alone for 8 weeks, and the experimental group was given sertraline and amisulpride for 8 weeks. Before and after the treatment, Yale Brown Obsessive-Compulsive Scale (Y-BOCS) was used to assess the severity of symptoms and TESS was used to assess the adverse reactions. Results: After 8 weeks of treatment, the total effective rate of the control and experimental groups were 66.7% and 90.1%. At 2 and 4 weeks of treatment, Y-BOCS score of the experimental group was lower than that of the control group (P<0.05). At 8 weeks of treatment, the Y-BOCS score in the experimental group was significantly lower than that in the control group (P<0.01). For intra-group comparison of the both groups, Y-BOCS score at each week of treatment decreased significantly compared with the score before treatment (P<0.01), except for at 2 weeks of treatment in the control group (no significant difference compared with the score before treat-ment). In light of the adverse reactions, increased salivation showed a significant difference between the 2 groups (P<0.05). Conclusion: Sertraline combined with amisulpride treatment on refractory OCD is better than sertraline monotherapy, showing earlier start of therapeutic efficacy, higher effective rate and more safe.关键词
难治性强迫症/舍曲林/氨磺必利Key words
refractory obsessive compulsive disorder/Sertraline/Amisulpride分类
医药卫生引用本文复制引用
万其容,胡亚荣,徐金枝,易军..舍曲林联合氨磺必利治疗难治性强迫症的临床研究[J].神经损伤与功能重建,2016,11(2):138-140,3.基金项目
湖北省自然科学基金 （）
