中国当代医药2016，Vol.23Issue(3)：11-14,4.
蜂胶对大鼠皮肤创伤愈合的影响
The effect of propolis on wound healing of skin in rats
摘要
Abstract
Objective To discuss the influence of propolis on wound healing and study preliminarily on the mechanism of wound healing. Methods 60 healthy and male Wistar rats were randomly divided into experimental group (wound model+propolis,n=20),control group (wound model+povidone iodine,n=20) and blank group (wound model+physiological saline,n=20).Each group was then randomly divided into 5 time points:3 d,5 d,7 d,10 d and 14 d with there were 4 rats in each time point.The wound model was established by full-thickness skin injury in ratsˊ back in size of 1 cm×1 cm, changed dressings every day.The rats were executed in every time point and the injuried skin tissues were cut to calcu-late the wound healing rate,and the change of wound histology was observed by hematoxylin-eosin (HE) staining and the dyanmic change of vascular endothelial growth factor(VEGF) and platelet-derived growth factor(PDGF) was detected by immunohistochemical staining method respectively. Results Compared with control group,the experimental group could obviously improve the healing speed and healing rate of wound in rats (P﹤0.05 or P﹤0.01).Compared with blank group,HE staining revealed that remarkable capillary and collagen fiber hyperplasia,and complete epidermal regenera-tion was observed in experimental group.Immunohistochemical staining revealed that the expression level of VEGF in experimental group was significantly higher than that of control group in 3 d (P﹤0.05).The expression level of PDGF was greatly higher than that of control group in 5 d (P﹤0.05). Conclusion The propolis plays a significant promotion role in healing and repair of wound,it may be related to promoting angiogenesis,the role of promoting proliferation of granulation tissue and scar tissue.promote the rebuilding of capillaries,acceletate the regeneration of the epidermis and facilitate the formation of scar.关键词
蜂胶/碘伏/创伤愈合/血管内皮生长因子/血小板源性生长因子/中草药Key words
Propolis/Povidone-iodine/Wound healing/Vascular endothelial growth factor/Platelet-derived growth fac-tor/Chinese herbal medicine分类
医药卫生引用本文复制引用
卞明心,沈若武,刘晓彤,李春雪,李玲,杨永华..蜂胶对大鼠皮肤创伤愈合的影响[J].中国当代医药,2016,23(3):11-14,4.基金项目
山东省高等学校科技计划项目 （）
