中国当代医药2016，Vol.23Issue(3)：77-80,4.
感冒清热颗粒的工艺研究
Process study of Ganmao Qingre Granule
李君 1刊永慧 1王春民 2闫春风 2郭金甲2
作者信息
- 1. 黑龙江中医药大学，哈尔滨 150040
- 2. 颈复康药业集团有限公司 河北省中药新辅料工程技术研究中心，河北承德 067000
- 折叠
摘要
Abstract
Objective To detect optimal preparation of Ganmao Qingre Granule (3 g per bag). Methods Volatile oil was extracted by CO2- supercritical fluid.The extraction technology was optimized targeting on oil extraction rate.The best process of volatile oil β-cyclodextrin (β-CD) inclusion was determined by orthogonal experimental design.Puerarin transfer rate as an indicator,extraction process was optimized.The granulation was processed by dry granulating. Results The optimal process on volatile oil extracting was 20 MPa in extraction pressure,35℃ in extraction temperature,and 120-minnute extraction under the condition of 30 kg/h CO2 flow rate.The best inclusion process of cyclodextrin was that the ratio of oil andβ-CD being 1:8,40℃ in constant temperature,and stirring inclusion for 1.5 h.The optimal decoction process included 8 times of water,twice in decoction,and 1.5 h each time. Conclusion Preparation technics of Ganmao Qingre Granule is stable and feasible.关键词
感冒清热颗粒/工艺改进/正交实验Key words
Ganmao Qingre Granule/Technology improvement/Orthogonal experiment分类
医药卫生引用本文复制引用
李君,刊永慧,王春民,闫春风,郭金甲..感冒清热颗粒的工艺研究[J].中国当代医药,2016,23(3):77-80,4.
