检验医学与临床2016，Vol.13Issue(8)：1045-1048,4.DOI:10.3969/j.issn.1672-9455.2016.08.015
CXCL2在结直肠癌中的表达及临床意义
Expression and clinical significance of CXCL2 in colorectal cancer
宋宏伟 1汪桂华 1王旭东 1朱惠君2
作者信息
- 1. 南通大学附属医院检验医学中心，江苏南通 226001
- 2. 南通大学附属医院病理科，江苏南通 226001
- 折叠
摘要
Abstract
Objective To detect the expression condition of chemokine (C‐X‐C motif) ligand 2 (CXCL2) in colorectal cancer (CRC) and to study its significance in clinical research .Methods The data of colorectal cancer CX‐CL2 mRNA expression in 6 independent research centers were analysed by using the Oncomine microarray database . The tissue microarray (TMA) immunohistochemistry staining was employed to characterize the expression of the CXCL2 protein in CRC .The correlation of CXCL2 expression with clinicopathological features and prognosis was an‐alyzed by statistics .Results CXCL2 was highly expressed in CRC tissues compared with corresponding peritumoral tissues .31 .31% of CXCL2 cytoplasm in CRC was highly expressed ,which was significantly correlated with the tumor location (P= 0 .022) ,infiltration extent of primary tumor (P= 0 .005) and lymph node metastasis (P=0 .017) .The Kaplan‐Meier and Cox regression analysis revealed that high CXCL2 expression was an independent pre‐dictive factor of poor prognosis in CRC .Conclusion High CXCL2 expression may be associated with invasion and metastasis of CRC ,which can be used as a prognostic index and potential target for the treatment of CRC .关键词
CXCL2/结直肠癌/组织芯片/免疫组化/预后Key words
CXCL2/colorectal cancer/tissue microarray/immunohistochemistry/prognosis引用本文复制引用
宋宏伟,汪桂华,王旭东,朱惠君..CXCL2在结直肠癌中的表达及临床意义[J].检验医学与临床,2016,13(8):1045-1048,4.
