摘要
Abstract
Objective To investigate the analgesic effect of dexmedetomidine combined with sufentanil after colon cancer operation .Methods Totally 118 cases of colon cancer radical operation under general anesthesia were randomly divided into the control group (sufentanil + lappaconitine + ramosetron by intravenous self control anal‐gesia) and the observation group (dexmedetomidine + sufentanil + lappaconitine + ramosetron by intravenous self control analgesia) ,59 cases in each group;the pain visual analogue scale (VAS) was adopted to evaluate the pain sit‐uation in the two groups at postoperative 1 ,3 ,6 ,12 ,24 ,48 h ,and the incision stimulating pain sensitive area and ad‐verse reactions were performed the statistics in the two groups .Results The VAS scores at various time pointsin the observation group were significantly lower than those in the control group ,the difference was statistically signifi‐cant(P<0 .05);the incision mechanical stimulating pain sensitive area at postoperative 24 ,48 ,72 h in the observation group were (12 .8 ± 2 .4) ,(24 .7 ± 2 .9) ,(23 .9 ± 3 .2)cm2 respectively ,which were significantly less than in (32 .9 ± 3 .6) ,(56 .8 ± 4 .1) ,(53 .6 ± 3 .6)cm2 in the control group ,the differences were statistically significant(P<0 .05) .No obvious adverse reactions occurred during the treatment period .Conclusion Using dexmedetomidine combined with sufentanil has better analgesic effect in colon cancer radical operation under general anesthesia .关键词
右美托咪定/舒芬太尼/全身麻醉/结肠癌根治术Key words
dexmedetomidine/sufentanil/general anaesthesia/colon cancer radical operation
