检验医学与临床2016，Vol.13Issue(8)：1071-1073,3.DOI:10.3969/j.issn.1672-9455.2016.08.024
西格列汀对2型糖尿病患者血清对氧磷酶及氧化应激水平影响研究
Influence of sitagliptin on serum PON1 and oxidative stress levels in patients with T2DM
詹鹏飞 1袁云燕 1梁致钰1
作者信息
- 1. 广东省汕头市中医医院检验科 515031
- 折叠
摘要
Abstract
Objective To investigate the influence of sitagliptin on serum PON1 and oxidative stress level in the patients with type 2 diabetes mellitus(T2DM ) .Methods Eighty patients with T2DM were enrolled in this study and divided into two groups :sitagliptin group and melbine group ,40 cases in each group .Other healthy persons of non‐diabetes were selected as the control group .The changes of serum levels of total anti‐oxidative status(TAS) ,to‐tal oxidative status(TOS) ,oxidative stress index(OSI) and paraoxonase(PON1) at entering the group and at 1 month of treatment were compared between the two groups .Results The levels of TAS and PON1 in two T2DM groups were significantly lower than those in the control group(P<0 .05) ,while the levels of TOS and OSI were significant‐ly higher than those in the control group(P<0 .05) .After treatment ,the levels of TAS and PON1 in the sitagliptin group were significantly increased compared with before treatment(P<0 .05) ,while the levels of TOS and OSI were significantly reduced (P<0 .05) .Conclusion Sitagliptin could reduce chronic oxidative stress injury in the patients with T2DM .关键词
西格列汀/2型糖尿病/对氧磷酶/氧化应激Key words
sitagliptin/type 2 diabetes mellitus/PON1/oxidative stress引用本文复制引用
詹鹏飞,袁云燕,梁致钰..西格列汀对2型糖尿病患者血清对氧磷酶及氧化应激水平影响研究[J].检验医学与临床,2016,13(8):1071-1073,3.
