国际眼科杂志2016，Vol.16Issue(4)：591-593,3.DOI:10.3980/j.issn.1672-5123.2016.4.01
丙烯醛诱导大鼠脉络膜新生血管的形成
The formation of rats’ choroidal neovascularization induced by acrolein
摘要
Abstract
AlM:To investigate the formation of rats′ choroidal neovascularization ( CNV) induced by acrolein.METHODS:Twelve Sprague-Dawley rats were randomly divided into three groups. Acrolein 200μL (2. 5 mg/kg/d) was poured into the rats′stomach for 4wk as acrolein 4wk and for 8wk as acrolein 8wk group. The same volume of fresh water was also done to the rats as the control group. Remove all eye balls and embed into paraffin with HE staining.RESLUTS:The RPE-Bruch membrane was intact with no obvious abnormality in the control group and acrolein 4wk group. Lost in the continuity of RPE and the movement of choroidal neovascularization were found in the acrolein 8wk.CONCLUSlON:The long time use of acrolein can induce the formation of choroial neovascularization in rats.关键词
丙烯醛/脉络膜新生血管/大鼠Key words
acrolein/choroidal neovascularization/rat引用本文复制引用
王观峰,邹秀兰,李东豪,王琛,李文立,皮荣标..丙烯醛诱导大鼠脉络膜新生血管的形成[J].国际眼科杂志,2016,16(4):591-593,3.基金项目
s：The Third Affiliated Hospital of Guangzhou Medical University Research Product ( No.2013 Y06) （ No.2013 Y06）
Guangdong Province Science and Technology Project (No.2012B031800419)基金项目:广州医科大学附属第三医院院内课题( No.2013Y06) （No.2012B031800419）
广东省科技厅课题(No.2012B031800419) （No.2012B031800419）
