摘要
Abstract
AlM: To compare posterior capsule opacification ( PCO ) after phacoemulsification cataract surgery with implantation of two different hydrophobic acrylic intraocular lenses ( lOLs) .METHODS: Such databases as PubMed ( 1980-Sep 2015),CBM(1990-Sep 2015),VlP(1989-Sep 2015),CNKl (1990-Sep 2015 ) and WanFang Data ( 1990-Sep 2015 ) were searched to collect the randomized controlled trials ( RCTs) about AcrySof 3-piece lOL vs Sensar 3-piece lOL for PCO or incidence of Nd:YAG laser capsulotomy. According to the inclusion and exclusion criteria, two reviewers independently screened the literatures, extracted data and assessed the quality of the included studies, then Meta - analysis was conducted using RevMan 5. 2 software.RESULTS: A total of 5 RCTs involving 1 036 eyes ( AcrySof group:553 eyes, Sensar group:483 eyes) were included, with a follow-up duration of 6mo ~ 2a. The results of Meta-analysis showed that:( 1 ) the incidence of PCO was significantly lower in AcrySof group than that in Sensar group(OR=0. 67,95%CI:0. 45~0. 99,P=0. 04);(2 ) the incidence of Nd:YAG laser capsulotomy after surgeries was similar between AcrySof group and Sensar group(OR=0. 57,95%CI:0. 32 ~1. 02,P=0. 06);(3) in an above 2a long - term follow - up subgroup analysis, AcrySof group indicated a significantly lower incidence of PCO(OR=0. 60,95%CI:0. 40 ~0. 91,P=0. 02), while the Nd: YAG laser capsulotomy incidence was similar between the two groups( OR=0. 60,95%CI:0. 33 ~1. 09,P=0. 09).CONCLUSlON: AcrySof 3-piece lOL seems to have a stronger preventive effect on PCO than Sensar 3-piece lOL. For the quantity limitation of the included studies, this conclusion still needs to be further proved by more high-quality RCTs.关键词
后囊膜混浊/后发性白内障/人工晶状体/Meta分析/系统评价Key words
posterior capsule opacification/after -cataract/intraocular lenses/Meta - analysis/systematic review
