国际眼科杂志2016，Vol.16Issue(4)：654-656,3.DOI:10.3980/j.issn.1672-5123.2016.4.16
细胞外基质重塑在原发性开角型青光眼的作用及研究进展
Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma
摘要
Abstract
Glaucoma is characterized by optic atrophy and visual field defect. The pathological elevated intraocular pressure is the leading risk factor for glaucoma. The pathological characteristic of glaucoma is apoptosis of retinal ganglion cells ( RGCs ) and their axon loss. Changes of the amounts and compositions of the extracellular matrix ( ECM ) play a crucial role in the structure of trabecular meshwork, lamina cribrose of opitic nerve head and the apoptosis of RGCs. The expression of transforming growth factor-β2 ( TGF-β2 ) increases in trabecular meshwork and aqueous humor for glaucomatic patients, which leads to elevated intraocular pressure by secretion and accumulation of ECM. Elevated intraocular pressure causes changes in ECM of optic nerve head and retina, resulting in blocked transport of neurotrophins, the high level of matrix metalloproteinase ( MMPs)-9 and low level of laminin respectively, which eventually lead to the apoptosis of RGCs. Therefore, it is important to understand the relationship between ECM and glaucoma, which may provide a new direction for glaucomatous pathogenesis and therapy.关键词
细胞外基质/原发性开角型青光眼/视网膜神经节细胞Key words
extracellular matrix/primary open angle glaucoma/retinal ganglion cells引用本文复制引用
庞宇,余玲..细胞外基质重塑在原发性开角型青光眼的作用及研究进展[J].国际眼科杂志,2016,16(4):654-656,3.基金项目
国家自然科学基金资助项目(No.81570841)@@@@National Natural Science Foundation of China (No.81570841) （No.81570841）
