国际眼科杂志2016，Vol.16Issue(4)：670-672,3.DOI:10.3980/j.issn.1672-5123.2016.4.20
糖尿病视网膜神经节细胞损伤的研究进展
Research advance of diabetic retinal ganglion cell lesions
李东洁 1吴迪 1张旭乡1
作者信息
- 1. 100053 中国北京市，首都医科大学宣武医院眼科
- 折叠
摘要
Abstract
Diabetic retinopathy ( DR ) is one of the severe complications of diabetes, which could lead to severe visual impairment. Retinal ganglion cell ( RGC) apoptosis has been confirmed both in vivo and in vitro prior to the definite micro - vascular damages. RGC impairment contributes to an early deterioration of vision. Hyperglycemia, oxidative stress, neuron growth factor deficiency and glutamate excitotoxicity were found to be involved in retinal ganglion cell apoptosis. Some neuron protective agents have been showed to prevent the apoptosis of RGC in experimental diabetic retinopathy. Clinical evidences about effectiveness and security also suggested potential treatments for the diabetic retinal neuron.关键词
糖尿病/视网膜神经节细胞/损伤机制/治疗Key words
diabetes/retinal ganglion cell/pathogenesis/treatment引用本文复制引用
李东洁,吴迪,张旭乡..糖尿病视网膜神经节细胞损伤的研究进展[J].国际眼科杂志,2016,16(4):670-672,3.
