中南医学科学杂志2016，Vol.44Issue(1)：34-37,4.DOI:10.15972/j.cnki.43-1509/r.2016.01.008
AIDS 患者血液与脑脊液中真菌检测及药敏分析
Analysis of Pathogenic Fungus Isolated from Blood and Cerebrospinal Fluid of AIDS Patients
摘要
Abstract
Objective To investigate the species and drug-resistance of pathogenic fungus isolated from blood and cerebrospinal fluid (CSF) of AIDS patients,so as to provide reference for clinical diagnosis and treatment. Methods The blood and CSF samples were collected from AIDS patients from a hospital for infectious diseases during 2011 to 2014. The pathogenic fungus were isolated and identified,then the drug sensitivity was analyzed. Results Totally 477 blood and 109 CSF specimens were analyzed,and the fungi positive rate were 66. 88% (319 / 477)and 66. 97% (73 / 109). A-mong the 477 blood samples,319 fungi strains were isolated and Penicillium marneffei was the main pathogens which posi-tive rate was 53. 04% (253 / 477). In the 109 CSF samples,73 fungi strains were isolated and the most common member was Cryptococcus neoformans whose positive rate was 66. 06% (72 / 109). Cryptococcus neoformans exihibited high sensi-tive to Amphotericin B,Fluconazole and 5-flucytosine. Conclusion AIDS patients have a high opportunity to co-infect with fungus,and the most isolates are P. marneffei and C. neoformans.关键词
艾滋病/马内非青霉菌/新生隐球菌/药物敏感性Key words
AIDS/Penicillium marneffei/Cryptococcus neoformans/drug sensitive分类
医药卫生引用本文复制引用
欧紫娟,陈胜华,蔡恒玲,杨赟,柏琴琴,陈丽丽..AIDS 患者血液与脑脊液中真菌检测及药敏分析[J].中南医学科学杂志,2016,44(1):34-37,4.基金项目
南华大学博士启动基金(2014XQD42) （2014XQD42）
