南京林业大学学报（自然科学版）2016，Vol.40Issue(2)：95-99,5.DOI:10.3969/j.issn.1000-2006.2016.02.016
PLGA基载药复合微球的制备及其释放性能
Preparation and drug release properties of PLGA complex microparticles
摘要
Abstract
Poly( lactic⁃co⁃glycolic acid) ( PLGA) microparticles were prepared by an emulsion⁃solvent evaporation tech⁃nique using bovine serum albumin ( BSA) as model drug. When the ratio of shell to core was 1∶1, ratio of water to oil 3∶5, dispersant concentration 0.5%, and the ultrasonic emulsification time 2 min, PLGA microparticles were 268.7 nm in diameter, characterized by the laser light scattering technique, and the drug content and drug encapsulation efficiency in this case were 30.88% and 46.95%, respectively. Scanning electron microscopy ( SEM) and transmission electron mi⁃croscope ( TEM) showed the products were spherical in shape and uniform in dimension. When the PLGA microparticles surface was modified with chitosan ( CS) by adsorption technique, the microparticle became larger in diameter. The presence of N element and the positive zeta potential of modified microparticles revealed the presence of CS on the sur⁃face of the PLGA microparticles. In vitro drug release test showed that the burst release of modified microparticles eased and the release time was prolonged compared with unmodified PLGA microparticles.关键词
聚乳酸-羟基乙酸(PLGA)/牛血清蛋白(BSA)/壳聚糖/微球/药物释放Key words
poly(lactide-co-glycolicacid) (PLGA)/bovine serum albumin (BSA)/chitosan/microparticle/drug release分类
化学化工引用本文复制引用
王芳,袁健,刘秀秀,方兵,杨思倩,高勤卫..PLGA基载药复合微球的制备及其释放性能[J].南京林业大学学报（自然科学版）,2016,40(2):95-99,5.基金项目
国家自然科学基金项目（31200451）；大学生实践创新训练计划项目（2013）；江苏高校优势学科建设工程资助项目 （）
