肿瘤预防与治疗2016，Vol.29Issue(1)：30-34,5.DOI:10.3969/j.issn.1674-0904.2016.01.006
药学干预改善胃癌患者生活质量的初步研究
Effects of Pharmaceutical Intervention on Quality of Life in Gastric Cancer Patients
摘要
Abstract
Objective:To observe the effects of pharmaceutical intervention on quality of life in gastric cancer pa-tients undergoing chemotherapy.Methods:One hundred and seventy-eight postoperative gastric cancer patients receiving chemotherapy in our institution between March 2012 and March 2014 were assigned into two groups randomly:intervention group(n =89;receiving chemotherapy plus pharmaceutical intervention)and control group(n =89;receiving chemotherapy only).The clinical pharmacists carried out pharmaceutical interventions according to the reaction of the medicines for the treatment of gastrointestinal symptoms during chemotherapy.The pharmacentical intervation included the communication with clinical doctors,optimizing the treatment plan and instruction for clinical medication.The gastrointestinal reactions during chemotherapy and the quality of life in two groups were observed.Results:The complete relief rates of the interven-tion group to the antemetics were 53.9%,61.8% and 64.0% in the first three cycle;those of the control group were 32.6%,43.8% and 46.1%,respectively.The difference was statistically significant between the two groups(P =0.004, P =0.016,P =0.016).The symptoms assessment of acute and delayed nausea in the intervention group were statistically lower than those in the control group(P =0.032,P =0.029).The symptoms assessment of acute and delayed vomiting in the intervention group were statistically lower than those in the control group(P =0.020,P =0.031).Quality of life evalu-ation showed that global health status score in the intervention group was higher than that in the control group(P =0.022), while the symptom scores in terms of loss of appetite and vomiting/nausea were lower than those in the control group (P =0.021,P =0.018).Conclusion:Pharmaceutical in-terventions can not only alleviate symptoms including nausea and vomiting but also improve the quality of life for gastric cancer patients who receive chemotherapy.关键词
药学干预/胃癌/化疗/生活质量Key words
Pharmaceutical Intervention/Gastric Cancer/Chemotherapy/Quality of Life分类
医药卫生引用本文复制引用
刘洋,尤振宇,苏晓辉,刘渤娜,刘学飞..药学干预改善胃癌患者生活质量的初步研究[J].肿瘤预防与治疗,2016,29(1):30-34,5.基金项目
辽宁省科学技术计划项目 （）
