神经病学与神经康复学杂志2016，Vol.12Issue(1)：24-28,5.DOI:10.12022/jnnr.2016-0026
诱导性多能干细胞及体细胞转分化技术治疗多发性硬化的研究进展
Advances in treatment with induced pluripotent stem cells and somatic cell transdifferentiation for multiple sclerosis
摘要
Abstract
Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of central nervous system and remains one of the major causes of disability in young adults. Conventional therapeutics can only prolong the remission duration, but do not cure it. Induced pluripotent stem cells (iPSCs) with the same totipotent differentiation as the stem cells have a broad prospect for application of cell replacement therapy in MS. Somatic cell reprogramming and trans differentiating can shorten the time for generating oligodendrocyte cell lineage, as compared with the traditional method with iPSCs, which provides a new idea for the treatment of MS. With the improved efficiency and quality in obtaining neural stem cells and oligodendrocytes, it is possible to have a big achievement in cell therapy for MS.关键词
多发性硬化/诱导性多能干细胞/转分化Key words
Multiple sclerosis/Induced pluripotent stem cells/Transdi昇erentiation引用本文复制引用
李梅,谢冲,管阳太..诱导性多能干细胞及体细胞转分化技术治疗多发性硬化的研究进展[J].神经病学与神经康复学杂志,2016,12(1):24-28,5.基金项目
国家自然科学基金重点项目（编号81230027）；国家自然科学基金面上项目（编号81471219）；上海市优秀学术带头人计划（编号14XD1403400）FUNDING/SUPPORT：Key Project of National Natural Science Foundation of China (No.81230027) （No.81230027）
General Project of National Natural Science Foundation of China (No.81471219) （No.81471219）
Outstanding Academic Leaders Planning of Shanghai  （）
Municipality (No.14XD1403400) （No.14XD1403400）
