神经病学与神经康复学杂志2016，Vol.12Issue(1)：47-51,5.DOI:10.12022/jnnr.2016-0015
MRI早期诊断阿尔茨海默病的研究进展
Advances in MRI in diagnosis of early-stage Alzheimer’sdisease
摘要
Abstract
With the aging of global population, the incidence of Alzheimer’s disease (AD) shows a significant upward trend. So far, there is still a lack of effective treatment for AD, and diagnosis, prevention and treatment in early stage of AD is the only effective way to delay the progression of AD. Currently, the diagnosis of AD still mainly relies on the exclusive method and clinical neuropsychological scales with poor repeatability and being absent of objective evidence, lacking sensitive and accurate methods for early diagnosis of AD. With the development of medical imaging technology, "medical imaging+" transdisciplinary research has become the new norm, the interdisciplinary neuroimaging techniques can clearly show the finer structures and lesions in the brain, which provides a basis for the early diagnosis of AD. Due to the loss of neurons in brain tissues of patients with AD, cerebral atrophy is developed, so the AD can be observed by measuring the degree of cerebral atrophy. This paper summarizes the research progress in measurement of hippocampal volume, entorhinal cortex thickness and the change of amygdale through magnetic resonance imaging (MRI), the application of double inversion recovery (DIR) sequence in diagnosis of AD, and the role of diffusion tensor imaging (DTI) in the assessment of injury in white matter related to hippocampus.关键词
阿尔茨海默病/早期诊断/磁共振成像Key words
Alzheimer disease/Early diagnosis/Magnetic resonance imaging引用本文复制引用
赵江民,詹青..MRI早期诊断阿尔茨海默病的研究进展[J].神经病学与神经康复学杂志,2016,12(1):47-51,5.基金项目
上海市科学技术委员会科技创新行动计划重点项目（编号10411953400）；上海市宝山区科学技术委员会科研项目（编号14-E-4）；上海市科学技术委员会医学引导类科技项目（编号114119a5800）FUNDING/SUPPORT：Key Project of Scientific & Technological Innovation Action Program Supported by Science and Technology Commission of Shanghai Municipality (No.10411953400) （No.10411953400）
Research Project Supported by Baoshan District Association for Science & Technology, Shanghai (No.14-E-4) （No.14-E-4）
Medical Guidance  （）
Project of Science and Technology Commission of Shanghai Municipality (No.114119a5800) （No.114119a5800）
