实用医学杂志2016，Vol.32Issue(3)：352-355,4.DOI:10.3969/j.issn.1006-5725.2016.03.004
芦荟多糖对实验性结肠炎大鼠肠黏膜的保护作用及其机制研究
The protection effect and mechanism of aloe polysaccharide on experimental colitis mucosa
摘要
Abstract
Objective To investigate the protective effect of aloe polysaccharide on experimental colitis mucosal. Methods The TNBS-induced experimental rat colitis model was successfully established and were treated by aloe polysaccharide, and enteric-coated tablets with sulfasalazine (SASP). Results DAI score, gross morphology score , histopathologic score and MPO in the model group were significantly higher than that in the normal group (P < 0.01), while those indicators were significantly lower after treatment (P < 0.01), IL-12 and IFN-γ mRNA and protein expressions in the model group were significantly higher than that in the normal group (P < 0.01), and IL-12 and IFN-γ expression levels in treatment group were significantly lower than that in the model group (P < 0.01), IL-4 and IL-13 mRNA and protein expression levels in the model group were significantly lower than that in the normal group (P < 0.01), and IL-4 and IL-13 expression in treatment group was significantly higher than that in the model group (P < 0.01). Conclusion Aloe polysaccharide on experimental colitis in rats has a good protective effect , of which mechanism may be reduced by IFN-γ and IL-12 levels, increased IL-4, IL-13 levels, and correct the imbalance of Thl/Th2.关键词
结肠炎/芦荟多糖/IL-4/IL-13/IFN-γ/IL-12Key words
Colitis/Aloe polysaccharide/IL-4/IL-13/IFN-γ/IL-12引用本文复制引用
张文志,欧水平,吴会超,于庆生..芦荟多糖对实验性结肠炎大鼠肠黏膜的保护作用及其机制研究[J].实用医学杂志,2016,32(3):352-355,4.基金项目
贵州省中药现代化科技产业研究开发专项项目 （）
