实用医学杂志2016，Vol.32Issue(4)：548-551,4.DOI:10.3969/j.issn.1006-5725.2016.04.012
广西巴马地区长寿人群沉默信号调节蛋白6基因mRNA的表达
mRNA expression of silent information regulator 6 among population in Bama county of Guangxi
摘要
Abstract
Objective To analyze mRNA expression of silent information regulator 6 (SIRT6) gene in the blood of population with family history of longevity in Bama county of Guangxi and to explore its association with SIRT6 gene polymorphism and its protein Methods One hundred and thirty-seven people (aged 30 ~ 106, 70 males, 67 females, 6.57% Han nationality, 93.43% Zhuang and Yao nationalities) with family history of longevity (long-lived family history group), and 91 people (aged 22~89, 51 males, 40 females, all Zhuang and Yao nationalities) without family history of longevity were recruited in the study (non-long-lived family history group). Real-time fluorescence quantitative RT-PCR was used to detect mRNA expression of SIRT6 gene in two groups. Results SIRT6 mRNA expression of total and femals in long-lived family history group were higher than those in non-long-lived family history group (P<0.05). mRNA expression of GG and CG genotype of SIRT6 (rs350846) and G allele carriers in long-lived family history group were all higher than those in non-long-lived family history group and the difference was statistically significant (P<0.05). SIRT6 mRNA expression was not associated with serum SIRT6 protein in long-lived family history group (P>0.05). Conclusion The expression of mRNA in SIRT6 gene may be associated with familial aggregation of longevity in Bama County of Guangxi and high expression of mRNA of SIRT6 in G allele carriers contributes to longevity.关键词
巴马/长寿/沉默信号调节蛋白6/mRNAKey words
Bama/Longevity/Silent information regulator 6/mRNA引用本文复制引用
蒋梅玉,黄倩倩,施礼威,夏天龙,梁雪,何敏,张志勇,覃健,韦霄..广西巴马地区长寿人群沉默信号调节蛋白6基因mRNA的表达[J].实用医学杂志,2016,32(4):548-551,4.基金项目
国家自然科学基金资助项目（编号81060246，81260423，61161009）；广西科学研究与技术开发项目（编号桂科攻14124005－2－11，桂科能0815011－6－5）；广西科学基金项目（编号桂科青0832032，桂科自0991115）；广西自然科学基金项目（编号2011GXNSFD018029，2012GXNSFBA053109）；高等学校博士学科点专项科研基金项目 （）
