实用医学杂志2016，Vol.32Issue(4)：573-576,4.DOI:10.3969/j.issn.1006-5725.2016.04.019
光动力联合细胞疗法治疗中晚期食管癌的临床疗效
Photodynamic therapy combined with cell therapies for advanced esophageal cancer
摘要
Abstract
Objective To explore the clinical efficacy and immunological effects of photodynamic therapy combined with cell therapies for advanced esophageal cancer. Methods Ninety patients with advanced esophageal cancer were collected and divided into three groups by a non-randomized controlled trial according to treatment intention. Group A (30 patients) received photodynamic therapy (PDT) alone; group B (30 patients), PDT received PDT plus cytokine-induced killer (CIK) cell therapies; and group C (30 patients) received CIK cell therapy aloen. In all the patients, the efficacy was assessed, the quality of life was documented, the immune function was detected, and the 6-month and 1-year death tolls were counted. Results The total clinical effectiveness rate was much higher in groups B and A than in group C (90.0% and 86.7% vs. 63.3%, P < 0.05), and there was no a statistical difference between group B and group A (P > 0.05). The rate of an increase in quality of life was significantly higher in group B than in groups A and C (86.7%vs. 60.0%and 33.3%, P<0.05), and it was higher in group A than in group C (60.0% vs. 33.3%, P < 0.05). As compared groups A and C, the percentages of CD3+ and CD3+ CD56+ were significantly improved in B group (P < 0.05), there was no a statistical difference between group A and group C. The 6-month survival rate did not differ statistically among the three groups (P > 0.05), while the 1-year survival rate was much higher in group B than in groups A and C (73.9% vs. 55.6% and 29.4%, P < 0.05). Conclusion Photodynamic therapy combined with cell therapies has a synergistic effect, and it enhances the overall immune function, significantly improves the quality of life and prolongs the survival period, showing a better clinical prospect.关键词
食管肿瘤/光动力治疗联合细胞因子诱导的杀伤细胞/免疫细胞趋化现象/临床效果Key words
Esophageal neoplasms/Photodynamic therapy combined with cytokine-induced killer cells/Immune cell chemotaxis/Curative effect引用本文复制引用
张明明,李娜,李秀莉,马文华,薄常文,安永辉,李康,马明..光动力联合细胞疗法治疗中晚期食管癌的临床疗效[J].实用医学杂志,2016,32(4):573-576,4.基金项目
重点科技研究计划项目 （）
