实用医学杂志2016，Vol.32Issue(5)：731-734,735,5.DOI:10.3969/j.issn.1006-5725.2016.05.014
2型糖尿病患者血尿酸与粒淋比相关性分析
The relationship between hyperuricemia with neutrophil-to-lymphocyte ratio and insulin resistance in type ;2 diabetes mellitus
摘要
Abstract
Objective To research the relationship between Serum uric acid (SUA) levels and the Neu-trophil-to-lymphocyte Ratio (NLR) of Type 2 Diabetes Mellitus (T2DM) patients. Method 273 newly diag-nosed T2DM patients are selected in accordance with the WHO diagnostic criteria: Male subjects with SUA lev-els ≥ 416 μmol/L(70 mg/L), and female subjects with SUA levels ≥ 357 μmol/L (60 mg/L) are sorted into the high SUA (HUA) group (224 subjects), and the rest into the normal SUA (NUA) group (49 subjects). 100 subjects were selected as a control group. One-Way analysis of variance was applied to the data of the three groups; Pearson correlation analysis was used to calculate the correlation of SUA levels , NLR and IR; risk fac-tors influencing SUA levels were analyzed with Logistic regression analysis; ROC curve analysis was used to de-termine the diagnostic value of NLR to HUA, and the optimal threshold value of NLR. Result (1) The NLR and IR of the HUA group was significantly higher than those of the NUA group (2.54 ± 0.63 vs. 2.05 ± 0.61, P < 0.001; 3.70 ± 1.86 vs. 2.71 ± 1.43, P < 0.001); (2) In the HUA group, UA was positively correlated with NLR and IR (respectively r = 0.480, P < 0.001; r = 0.332, P < 0.001). (3)NLR (P < 0.001, EXP(B)= 8.045, 95%CI = 4.597 ~ 14.079) was a risk factor of Hyperuricemia. Conclusion Our results suggest that NLR may be an independent risk factor of Hyperuricemia.关键词
2型糖尿病/血尿酸/中性粒细胞/淋巴细胞比率/胰岛素抵抗Key words
Type 2 diabetes mellitus/Neutrophil-to-lymphocyte ratio/Serum uric acid/Insulin re-sistance引用本文复制引用
黄伊华,罗鹏,余思渊,唐如,彭奕贤,何雷..2型糖尿病患者血尿酸与粒淋比相关性分析[J].实用医学杂志,2016,32(5):731-734,735,5.基金项目
广东省医学科研基金资助 （）
