实用医学杂志2016，Vol.32Issue(5)：750-753,4.DOI:10.3969/j.issn.1006-5725.2016.05.019
细胞DNA定量分析技术在尿路上皮癌诊断中的应用价值
Application of DNA-image cytometry in the diagnose of urothelial cell carcinomas
摘要
Abstract
Objective To investigate the value of DNA-image cyt-ometry (DNA-ICM) in the diagnosis of urothelial cell carcinomas (UCC). Methods Totally 162 voided urine specimens (92 cases from urothel-ial car-cinomas patients and 70 cases from benign urinary system diseases patients ) were detected with DNA-ICM and liquid-based cytology (LBC), respectively. Results The sensitivity and specificity of DNA-ICM were 65.2%and 100% respectively in the diagnosis of UCC but those of LBC were 27.2% and 98.6%, respectively. The sensitivity of DNA-ICM was significantly higher than that of LBC in the diagnosis of UCC (P < 0.01). The sen-sitivity of DNA-ICM in upper urinary tract urothelial cell carcinomas (UTUC) were 77.1%, which was much higher than that in bladder urothelial cell carcinomas (57.9%) but no statistical significance was found (P >0.01). Conclusion DNA-ICM, which improves the positive rate of urinary cytology, has great application value in the diagnosis of urothelial cell carcinomas and it is an effective screening method for urothelial cancer in diag-nosis and follow-up.关键词
尿路上皮癌/DNA倍体/DNA定量分析系统/液基细胞学Key words
Urothelial cell carcinomas/DNA ploidy/DNA-image cytometry/Liquid-based cytology引用本文复制引用
苏杰,陶伟,张培,梁朝朝,李俊..细胞DNA定量分析技术在尿路上皮癌诊断中的应用价值[J].实用医学杂志,2016,32(5):750-753,4.基金项目
卫生部医药卫生科技发展研究项目基金资助项目 （）
